{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:09:50Z","timestamp":1788869390032,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation grants of China","doi-asserted-by":"crossref","award":["81402606"],"award-info":[{"award-number":["81402606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Summary<\/jats:title>\n \n Progranulin (\n PGRN<\/jats:styled-content>\n ) is a multi\u2010functional protein known to be involved in inflammation. Recent studies have found that\n PGRN<\/jats:styled-content>\n has dual roles in inflammation and exerts anti\u2010inflammatory and pro\u2010inflammatory function in different diseases. However, the role of\n PGRN<\/jats:styled-content>\n in psoriasis has not been fully elucidated. Here, we detected preferential expression of\n PGRN<\/jats:styled-content>\n in human psoriatic lesions and serum. Moreover, serum\n PGRN<\/jats:styled-content>\n \/tumour necrosis factor\u2010\n \u03b1<\/jats:italic>\n ratio was negatively correlated with disease severity. To investigate the role of\n PGRN<\/jats:styled-content>\n in the pathogenesis of psoriasis, we used wild\u2010type (\n WT<\/jats:styled-content>\n ) and\n PGRN<\/jats:styled-content>\n \u2212\/\u2212<\/jats:sup>\n mice in a model of 12\u2010\n O<\/jats:italic>\n \u2010tetradecanoylphorbol 13\u2010acetate (\n TPA<\/jats:styled-content>\n ) \u2010induced psoriasis\u2010like inflammation. We demonstrated that\n PGRN<\/jats:styled-content>\n expression was dramatically enhanced in the psoriasis\u2010like lesions of\n TPA<\/jats:styled-content>\n \u2010treated\n WT<\/jats:styled-content>\n mice, in accordance with human psoriatic lesions. Surprisingly,\n PGRN<\/jats:styled-content>\n \u2212\/\u2212<\/jats:sup>\n mice were more sensitive to the development of\n TPA<\/jats:styled-content>\n \u2010induced psoriasis\u2010like inflammation. The mechanism underlying this increased sensitivity of\n PGRN<\/jats:styled-content>\n \u2212\/\u2212<\/jats:sup>\n mice to\n TPA<\/jats:styled-content>\n \u2010induced psoriasis\u2010like inflammation was impaired differentiation of regulatory T cells in lymph nodes and decreased recruitment of these cells in the affected skin, which results in more severe inflammation. Hence, in\n WT<\/jats:styled-content>\n mice,\n PGRN<\/jats:styled-content>\n promotes differentiation and recruitment of regulatory T cells at the site of inflammation, which protects the skin from an exaggerated psoriasis\u2010like inflammatory response.\n <\/jats:p>","DOI":"10.1111\/imm.12446","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T10:50:11Z","timestamp":1422355811000},"page":"279-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis\u2010like skin inflammation"],"prefix":"10.1111","volume":"145","author":[{"given":"Kun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"Department of Laboratory Medicine Key Laboratory of Diagnostic Medicine designated by the Ministry of Education Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Key Laboratory of Diagnostic Medicine designated by the Ministry of Education Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Key Laboratory of Diagnostic Medicine designated by the Ministry of Education Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Key Laboratory of Diagnostic Medicine designated by the Ministry of Education Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Key Laboratory of Diagnostic Medicine designated by the Ministry of Education Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05663"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0996-747"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800713"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm816"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200900086"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04275.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200712039"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0812429"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199214"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.04.065"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.04.037"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.10.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.12.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101068"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00425-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2006.pto_298.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-144659"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.11.063"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63113"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt178"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018266"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.06.004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09633.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22699"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08504.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000238305"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.068"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903719"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12241"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12446","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:51:31Z","timestamp":1696164691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/imm.12446"],"URL":"https:\/\/doi.org\/10.1111\/imm.12446","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]},"assertion":[{"value":"2014-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}