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Although molecular events leading to genital tissue presentation and cellular architectural remodelling are unclear, early\u2010stage host immune responses are believed to contribute to these long\u2010term sequelae. Recently, we reported the contribution of selected infection\u2010associated micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (miRs) in the generation of host immunity at early\u2010stage infection (day 6 after intravaginal <jats:italic>Chlamydia muridarum<\/jats:italic> challenge in C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice). In this report, we describe the contribution of an infection\u2010associated micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>, i.e. miR\u2010214, to host immunity. <jats:italic>Chlamydia muridarum<\/jats:italic> infection in the C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mouse genital tract significantly down\u2010regulated miR\u2010214 while up\u2010regulating intracellular adhesion molecule 1 (<jats:italic><jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>1<\/jats:italic>) gene expression. These <jats:italic>in\u00a0vivo<\/jats:italic> observations were confirmed by establishing direct regulation of <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 by miR\u2010214 in <jats:italic>ex\u00a0vivo<\/jats:italic> genital cell cultures in the presence of miR\u2010214 mimic and inhibitor. Because, <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 contributes to recruitment of neutrophils following infection, we also demonstrated that alteration of <jats:italic><jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>1<\/jats:italic> by miR\u2010214 in interleukin\u201017<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2010deficient (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A<jats:sup>\u2212\/\u2212<\/jats:sup>) mice correlated with reduction of neutrophils infiltrating genital tissue at day 6 after challenge. Additionally, these early\u2010stage events resulted in significantly decreased genital pathology in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A<jats:sup>\u2212\/\u2212<\/jats:sup> mice compared with C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice. This report provides evidence for early\u2010stage regulation of <jats:italic><jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>1<\/jats:italic> by micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s, resulting in reduction of genital pathology associated with chlamydial infection.<\/jats:p>","DOI":"10.1111\/imm.12470","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T10:26:34Z","timestamp":1428661594000},"page":"534-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Murine Micro<scp>RNA<\/scp>\u2010214 regulates intracellular adhesion molecule (<i>ICAM1<\/i>) gene expression in genital <i><scp>C<\/scp>hlamydia muridarum<\/i> infection"],"prefix":"10.1111","volume":"145","author":[{"given":"Tanvi","family":"Arkatkar","sequence":"first","affiliation":[{"name":"South Texas Center for Emerging Infectious Diseases and Center of Excellence in Infection Genomics University of Texas at San Antonio San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishein","family":"Gupta","sequence":"additional","affiliation":[{"name":"South Texas Center for Emerging Infectious Diseases and Center of Excellence in Infection Genomics University of Texas at San Antonio San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Midwestern University Downers Grove IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-3366","authenticated-orcid":false,"given":"Jieh\u2010Juen","family":"Yu","sequence":"additional","affiliation":[{"name":"South Texas Center for Emerging Infectious Diseases and Center of Excellence in Infection Genomics University of Texas at San Antonio San Antonio TX 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