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Currently, there is no vaccine or specific treatment available. Further investigation on dengue pathogenesis is required to better understand the disease and to identify potential therapeutic targets. The chemokine system has been implicated in dengue pathogenesis, although the specific role of chemokines and their receptors remains elusive. Here we describe the role of the <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\u2010chemokine receptor <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5 in Dengue virus (<jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>\u20102) infection. <jats:italic>In vitro<\/jats:italic> experiments showed that <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5 is a host factor required for <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>\u20102 replication in human and mouse macrophages. <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>\u20102 infection induces the expression of <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5 ligands. Incubation with an antagonist prevents <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5 activation and reduces <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>\u20102 positive\u2010stranded (+) <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> inside macrophages. Using an immunocompetent mouse model of <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>\u20102 infection we found that <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5<jats:sup>\u2212\/\u2212<\/jats:sup> mice were resistant to lethal infection, presenting at least 100\u2010fold reduction of viral load in target organs and significant reduction in disease severity. This phenotype was reproduced in wild\u2010type mice treated with <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5\u2010blocking compounds. Therefore, <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5 is a host factor required for <jats:styled-content style=\"fixed-case\">DENV<\/jats:styled-content>\u20102 replication and disease development. Targeting <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5 might represent a therapeutic strategy for dengue fever. These data bring new insights on the association between viral infections and the chemokine receptor <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>5.<\/jats:p>","DOI":"10.1111\/imm.12476","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T14:37:02Z","timestamp":1430750222000},"page":"583-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Dengue virus requires the CC\u2010chemokine receptor CCR5 for replication and infection development"],"prefix":"10.1111","volume":"145","author":[{"given":"Rafael E.","family":"Marques","sequence":"first","affiliation":[{"name":"Immunopharmacology Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4005-1753","authenticated-orcid":false,"given":"Rodrigo","family":"Guabiraba","sequence":"additional","affiliation":[{"name":"INRA Infectiologie et Sant\u00e9 Publique , UMR1282 Nouzilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana L.","family":"Del Sarto","sequence":"additional","affiliation":[{"name":"Immunopharmacology Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca F.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Immunopharmacology Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Immunopharmacology Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cisalpino","sequence":"additional","affiliation":[{"name":"Microorganism\/Host Interaction Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro E.","family":"Marques","sequence":"additional","affiliation":[{"name":"Immunobiophotonics Departamento de Morfologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina C.","family":"Pacca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Virologia Departamento de Doen\u00e7as Dermatol\u00f3gicas Infecciosas e Parasit\u00e1rias Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio T.","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Microorganism\/Host Interaction Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo B.","family":"Menezes","sequence":"additional","affiliation":[{"name":"Immunobiophotonics Departamento de Morfologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio L.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Virologia Departamento de Doen\u00e7as Dermatol\u00f3gicas Infecciosas e Parasit\u00e1rias Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle G.","family":"Souza","sequence":"additional","affiliation":[{"name":"Microorganism\/Host Interaction Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro M.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Immunopharmacology Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.Global strategy for dengue prevention and control 2012\u20132020. 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