{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:20:00Z","timestamp":1784305200707,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL110170"],"award-info":[{"award-number":["R01HL110170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY07739"],"award-info":[{"award-number":["R01 EY07739"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study tested the hypothesis that peripheral immune challenges will produce predictable activation patterns in the rat brain consistent with sympathetic excitation. As part of examining this hypothesis, this study asked whether central activation is dependent on capsaicin\u2010sensitive C\u2010fibres. We induced skin contact sensitivity immune responses with 2,4\u2010dinitrochlorobenzene (<jats:styled-content style=\"fixed-case\">DNCB<\/jats:styled-content>), in the presence or absence of the acute C\u2010fibre toxin capsaicin (8\u2010methyl\u2010<jats:italic>N<\/jats:italic>\u2010vanillyl\u20106\u2010nonenamide) to trigger immune responses with and without diminished activity of C\u2010fibres. Innovative blood\u2010oxygen\u2010level\u2010dependent functional magnetic resonance imaging data revealed that the skin contact sensitivity immune responses induced with <jats:styled-content style=\"fixed-case\">DNCB<\/jats:styled-content> were associated with localized increases in brain neuronal activity in treated rats. This response was diminished by pre\u2010treatment with capsaicin 1\u00a0week before scans. In the same animals, we found expression of the immediate early gene c\u2010Fos in sub\u2010regions of the amygdala and hypothalamic sympathetic brain nuclei. Significant increases in c\u2010Fos expression were found in the supraoptic nucleus, central amygdala and medial habenula following immune challenges. Our results support the idea that selective brain regions, some of which are associated with sympathetic function, process or modulate immune function through pathways that are partially dependent on C\u2010fibres. Together with previous studies demonstrating the motor control pathways from brain to immune targets, these findings indicate a central neuroimmune system to monitor host status and coordinate appropriate host responses.<\/jats:p>","DOI":"10.1111\/imm.12479","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T09:07:20Z","timestamp":1431508040000},"page":"206-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Central neural activation following contact sensitivity peripheral immune challenge: evidence of brain\u2013immune regulation through <scp>C<\/scp> fibres"],"prefix":"10.1111","volume":"146","author":[{"given":"Jeffrey S.","family":"Thinschmidt","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics University of Florida &amp; North Florida\/South Georgia VA Medical Center Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics University of Florida &amp; North Florida\/South Georgia VA Medical Center Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Korah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics University of Florida &amp; North Florida\/South Georgia VA Medical Center Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo D.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Febo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaleel","family":"Miyan","sequence":"additional","affiliation":[{"name":"Neurobiology Research Group Faculty of Life Sciences The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria B.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Eugene and Marilyn Glick Eye Institute Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2012.753960"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.4.767"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12338505"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.032797"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/363159a0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337516"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.1997.16"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01786.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00534.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.4049\/jimmunol.154.7.3056","article-title":"Inhibition of the induction of delayed\u2010type and contact hypersensitivity by calcitonin gene\u2010related peptide","volume":"154","author":"Asahina A","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2683"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.09.038"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.04.008"},{"key":"e_1_2_8_16_1","first-page":"363","article-title":"The spinothalamic tract","volume":"5","author":"Hodge CJ","year":"1990","journal-title":"Crit Rev Neurobiol"},{"key":"e_1_2_8_17_1","volume-title":"Neuroscience","author":"Purves D","year":"2004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075015"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01321"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)11105-R"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(96)00098-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)00217-O"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1331"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.03.060"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0319-1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3156-04.2005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1049"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(89)90079-1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb12758.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.07.008"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01808.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.2733092.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.04.051"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1651"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1152\/ajplegacy.1974.227.1.114","article-title":"Adrenomedullary pressor responses during posterior hypothalamic stimulation","volume":"227","author":"Eferakeya A","year":"1974","journal-title":"Am J Physiol"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235648"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000123111"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990428)407:1<130::AID-CNE10>3.0.CO;2-8"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.607207"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00002.2003"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-004-0220-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2010.12.007"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1993.1006"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066821"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.046"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06671.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(98)00023-0"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.09.013"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.4.0436"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-06-01145.1983"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90980-X"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2004.07.005"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-073X.2006.00141.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.042028"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90369-X"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-02-00897.1994"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12479","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T21:36:48Z","timestamp":1696196208000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,24]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/imm.12479"],"URL":"https:\/\/doi.org\/10.1111\/imm.12479","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,24]]},"assertion":[{"value":"2015-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}