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Recent reports have suggested that inflammation of lungs due to <jats:italic>S.\u00a0pneumoniae<\/jats:italic> infection promotes bacterial dissemination and severe disease. However, the contribution of anti\u2010inflammatory molecules to the pathogenesis of <jats:italic>S.\u00a0pneumoniae<\/jats:italic> remains unknown. To elucidate whether the production of the anti\u2010inflammatory cytokine interleukin\u201010 (IL\u201010) is beneficial or detrimental for the host during pneumococcal pneumonia, we performed <jats:italic>S.\u00a0pneumoniae<\/jats:italic> infections in mice lacking IL\u201010 (IL\u201010<jats:sup>\u2212\/\u2212<\/jats:sup> mice). The IL\u201010<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed increased mortality, higher expression of pro\u2010inflammatory cytokines, and an exacerbated recruitment of neutrophils into the lungs after <jats:italic>S.\u00a0pneumoniae<\/jats:italic> infection. However, IL\u201010<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed significantly lower bacterial loads in lungs, spleen, brain and blood, when compared with mice that produced this cytokine. Our results support the notion that production of IL\u201010 during <jats:italic>S.\u00a0pneumoniae<\/jats:italic> infection modulates the expression of pro\u2010inflammatory cytokines and the infiltration of neutrophils into the lungs. This feature of IL\u201010 is important to avoid excessive inflammation of tissues and to improve host survival, even though bacterial dissemination is less efficient in the absence of this cytokine.<\/jats:p>","DOI":"10.1111\/imm.12486","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T14:59:50Z","timestamp":1433170790000},"page":"100-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Interleukin\u201010 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by <i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1111","volume":"146","author":[{"given":"Hern\u00e1n F.","family":"Pe\u00f1aloza","sequence":"first","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile 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