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Disease develops after inhalation of <jats:italic>Paracoccidioides brasiliensis<\/jats:italic> conidia followed by an improper immune activation by the host leucocytes. Dendritic cells (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s) are antigen\u2010presenting cells with the unique ability to direct the adaptive immune response by the time of activation of naive T cells. This study was conducted to test whether extracts of <jats:italic>P. brasiliensis<\/jats:italic> would induce maturation of <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s. We found that <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s treated with extracts acquired an inflammatory phenotype and upon adoptive transfer conferred protection to infection. Interestingly, interleukin\u201010 production by <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells was ablated following <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> transfer. Further analyses showed that lymphocytes from infected mice were high producers of interleukin\u201010, with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells being the main source. Blockage of cross\u2010presentation to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells by modulated <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s abolished the protective effect of adoptive transfer. Collectively, our data show that adoptive transfer of <jats:italic>P. brasiliensis<\/jats:italic>\u2010modulated <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s is an interesting approach for the control of infection in paracoccidioidomycosis.<\/jats:p>","DOI":"10.1111\/imm.12526","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T17:14:26Z","timestamp":1440436466000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protection against <i>Paracoccidioides brasiliensis<\/i> infection in mice treated with modulated dendritic cells relies on inhibition of interleukin\u201010 production by <scp>CD<\/scp>8<sup>+<\/sup> T cells"],"prefix":"10.1111","volume":"146","author":[{"given":"Thiago","family":"Alves da Costa","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology Institute of Biology University of Campinas 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