{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:37:00Z","timestamp":1791265020451,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Summary<\/jats:title>To further investigate the contribution of intercellular adhesion molecule\u20101 (ICAM<\/jats:styled-content>\u20101) to adaptive immune responses, we analysed T\u2010cell development and function in mice lacking full\u2010length ICAM<\/jats:styled-content>\u20101 (ICAM<\/jats:styled-content>\u20101tm1Jcgr<\/jats:italic><\/jats:sup>). Compared with wild\u2010type (ICAM<\/jats:styled-content>\u20101WT<\/jats:italic><\/jats:sup><\/jats:styled-content>) mice, ICAM<\/jats:styled-content>\u20101tm1Jcgr<\/jats:italic><\/jats:sup> mice have impaired thymocyte development. Proportions and numbers of double negative, double positive, mature CD<\/jats:styled-content>4+<\/jats:sup> and CD<\/jats:styled-content>8+<\/jats:sup> thymocytes, as well as of regulatory T (Treg) cells were also significantly decreased. In the periphery, ICAM<\/jats:styled-content>\u20101tm1Jcgr<\/jats:italic><\/jats:sup> mice had significantly decreased proportions and numbers of naive and activated\/memory CD<\/jats:styled-content>4+<\/jats:sup> and CD<\/jats:styled-content>8+<\/jats:sup> T cells, as well as of Treg cells, in lymph nodes but not in the spleen. In vitro<\/jats:italic> activation of CD<\/jats:styled-content>4+<\/jats:sup> and CD<\/jats:styled-content>8+<\/jats:sup> T cells from ICAM<\/jats:styled-content>\u20101tm1Jcgr<\/jats:italic><\/jats:sup> mice with anti\u2010CD<\/jats:styled-content>3 antibodies and antigen\u2010presenting cells (APC<\/jats:styled-content>s) resulted in a significantly weaker proliferation, whereas proliferation induced with anti\u2010CD<\/jats:styled-content>3 and anti\u2010CD<\/jats:styled-content>28 antibody\u2010coated beads was normal. In vivo<\/jats:italic> immunization of ICAM<\/jats:styled-content>\u20101tm1Jcgr<\/jats:italic><\/jats:sup> mice resulted in normal generation of specific effector and memory immune responses that protect against a viral challenge. However, contrary to ICAM<\/jats:styled-content>\u20101WT<\/jats:italic><\/jats:sup><\/jats:styled-content> mice, immunization\u2010induced specific effectors could not eradicate immunogen\u2010expressing tumours. Treg cells from ICAM<\/jats:styled-content>\u20101tm1Jcgr<\/jats:italic><\/jats:sup> mice have abnormal activation and proliferation induced by anti\u2010CD<\/jats:styled-content>3 antibody and APC<\/jats:styled-content>s, and have markedly decreased suppressive activity in\u00a0vitro<\/jats:italic>. In contrast to ICAM<\/jats:styled-content>\u20101WT<\/jats:italic><\/jats:sup><\/jats:styled-content> mice, they were unable to control experimentally induced colitis in\u00a0vivo<\/jats:italic>. Hence, our results further highlight the pleiotropic role of ICAM<\/jats:styled-content>\u20101 in T\u2010cell\u2010dependent immune responses, with a major role in Treg cell development and suppressive function.<\/jats:p>","DOI":"10.1111\/imm.12533","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T02:02:05Z","timestamp":1442282525000},"page":"657-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Regulatory T\u2010cell development and function are impaired in mice lacking membrane expression of full length intercellular adhesion molecule\u20101"],"prefix":"10.1111","volume":"146","author":[{"given":"Ga\u00eblle","family":"Gottrand","sequence":"first","affiliation":[{"name":"Immunology\u2010Immunopathology\u2010Immunotherapy UPMC Univ Paris 06 UMRS_959 Sorbonne Universit\u00e9s Paris France"},{"name":"Immunology\u2010Immunopathology\u2010Immunotherapy FRE3632 CNRS Paris 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