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In the present study, the role of interleukin\u201017A (\n IL<\/jats:styled-content>\n \u201017A) in angiogenesis in the process of ocular\n NV<\/jats:styled-content>\n both\n in vivo<\/jats:italic>\n and\n in vitro<\/jats:italic>\n was investigated. Also, a paracrine role of\n IL<\/jats:styled-content>\n \u201017A was demonstrated in the crosstalk between endothelial cells and macrophages in angiogenesis. In the retinas of mice with retinopathy of prematurity, the\n IL<\/jats:styled-content>\n \u201017A expression increased significantly at postnatal day 15 (P15) and P18 during retinal\n NV<\/jats:styled-content>\n . Mice given\n IL<\/jats:styled-content>\n \u201017A neutralizing antibody (\n NA<\/jats:styled-content>\n b) developed significantly reduced choroidal\n NV<\/jats:styled-content>\n and retinal\n NV<\/jats:styled-content>\n . Studies on vascular endothelial growth factor (\n VEGF<\/jats:styled-content>\n ) over\u2010expressing mice suggested that\n IL<\/jats:styled-content>\n \u201017A modulated\n NV<\/jats:styled-content>\n through the\n VEGF<\/jats:styled-content>\n pathway. Furthermore,\n IL<\/jats:styled-content>\n \u201017A deficiency shifted macrophage polarization toward an M2 phenotype during retinal\n NV<\/jats:styled-content>\n with significantly reduced M1 cytokine expression compared with wild\u2010type controls.\n In vitro<\/jats:italic>\n assays revealed that\n IL<\/jats:styled-content>\n \u201017A treated macrophage supernatant gave rise to elevated human umbilical vascular endothelial cell proliferation, tube formation and\n VEGF<\/jats:styled-content>\n receptor 1 and receptor 2 expression. Therefore,\n IL<\/jats:styled-content>\n \u201017A could potentially serve as a novel target for treating ocular\n NV<\/jats:styled-content>\n diseases. The limitation of this study involved the potential mechanisms, such as which transcription accounted for macrophage polarization and how the subsequent cytokines were modulated when macrophages were polarized. Further studies need to be undertaken to definitively determine the extent to which\n IL<\/jats:styled-content>\n \u201017A neutralizing anti\u2010angiogenic activity depends on macrophage modulation compared with anti\u2010\n VEGF<\/jats:styled-content>\n treatment.\n <\/jats:p>","DOI":"10.1111\/imm.12571","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T03:27:34Z","timestamp":1450841254000},"page":"414-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Interleukin\u201017A neutralization alleviated ocular neovascularization by promoting M2 and mitigating M1 macrophage polarization"],"prefix":"10.1111","volume":"147","author":[{"given":"Yanji","family":"Zhu","sequence":"first","affiliation":[{"name":"The Department of Ophthalmology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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