{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:55:35Z","timestamp":1773420935693,"version":"3.50.1"},"reference-count":217,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immune imbalance in autoimmune disorders such as type 1 diabetes may originate from aberrant activities of effector cells or dysfunction of suppressor cells. All possible defective mechanisms have been proposed for diabetes\u2010prone species: (i) quantitative dominance of diabetogenic cells and decreased numbers of regulatory T cells, (ii) excessive aggression of effectors and defective function of suppressors, (iii) perturbed interaction between effector and suppressor cells, and (iv) variations in sensitivity to negative regulation. The experimental evidence available to date presents conflicting information on these mechanisms, with identification of perturbed equilibrium on the one hand and negation of critical role of each mechanism in propagation of diabetic autoimmunity on the other hand. In our analysis, there is no evidence that inherent abnormalities in numbers and function of effector and suppressor T cells are responsible for the immune imbalance responsible for propagation of type 1 diabetes as a chronic inflammatory process. Possibly, the experimental tools for investigation of these features of immune activity are still underdeveloped and lack sufficient resolution, in the presence of the extensive biological viability and functional versatility of effector and suppressor elements.<\/jats:p>","DOI":"10.1111\/imm.12581","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T19:15:43Z","timestamp":1452453343000},"page":"377-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mechanisms of autoimmunity in the non\u2010obese diabetic mouse: effector\/regulatory cell equilibrium during peak inflammation"],"prefix":"10.1111","volume":"147","author":[{"given":"Nadir","family":"Askenasy","sequence":"first","affiliation":[{"name":"The Leah and Edward M. Frankel Laboratory of Experimental Bone Marrow Transplantation Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2260"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80392-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1502"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115643"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-395-0_17"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-010-0204-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0438-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100135"},{"key":"e_1_2_9_10_1","article-title":"Mechanisms of diabetic autoimmunity: I. The inductive interface between islets and the immune system at onset of inflammation","author":"Askenasy N","year":"2015","journal-title":"Immunol Res"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.12.004"},{"key":"e_1_2_9_12_1","article-title":"Mechanisms of diabetic autoimmunity: II. Is diabetes a central or peripheral disorder of effector and rregulatory cells?","author":"Askenasy N","year":"2015","journal-title":"Immunol Res"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF02918546","article-title":"Disordered cellular immunity in type I diabetes of man and the BB rat","volume":"1","author":"Buse JB","year":"1982","journal-title":"Surv Immunol Res"},{"key":"e_1_2_9_14_1","first-page":"32","article-title":"Cell\u2010mediated immunity in type I (insulin\u2010dependent) diabetes of man and the BB rat","volume":"2","author":"Naji A","year":"1985","journal-title":"Concepts Immunopathol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.001143"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.3.331"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.7.11.8370480"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1089-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(05)87004-X"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780249155"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.04.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2787"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2012.10.003"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb06153.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80068-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1995.0097"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.2.299"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01102-X"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979798"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1996.0033"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0250625"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.1352"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1113"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838475"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76238"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90730-E"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903213993"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.07.337"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0332"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2005.05.003"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1207857"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.5.1415"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100093"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.4040"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323328"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12277"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.3.1388"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.07.008"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939408"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913835107"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242435"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018975108"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.752462"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.14.6167"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.3.308"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901587"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01213.x"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/35021081"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6051"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.6473"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.07.002"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301927"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6039"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7144"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0530"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07657"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1250"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2746"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2030"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030913"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0019-2805.2003.01804.x"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0383"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.289488"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1637"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324285"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.7.815"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.3.1283"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00370-8"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104649"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3516"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6900"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018973108"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1131954100"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.9.1992"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00335-6"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-192120"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.05.019"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2000012)30:12<3380::AID-IMMU3380>3.0.CO;2-P"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.2.672"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810713105"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-139964"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6616(03)00049-4"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00025-8"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.7.4407"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400606"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021630"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/366069a0"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240820"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0932778100"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011353"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1466"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)10053-8"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939809008041"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.2.331"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324405"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.02.015"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.04.004"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.8.3912"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.8.1493"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.07.028"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-2-63"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025160614313"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.1.72"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.5.1669"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.3.1151"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.08.003"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2636971100"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni904"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_9_120_1","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.4049\/jimmunol.161.5.2620","article-title":"Mature mainstream TCR\u2010\u03b1\u03b2\n                  + CD4+ thymocytes expressing L\u2010selectin mediate \u201cactive tolerance\u201d in the nonobese diabetic mouse","volume":"161","author":"Herbelin A","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.240"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80195-8"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041982"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2010.548839"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03860.x"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172382999"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042398"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-0810"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2011.568553"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0213605"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.327"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02546.x"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1700"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.1.92"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2004.11.004"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1248"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2013.866103"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1604-4"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708899104"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243142"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni726"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.4295"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm924"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7308"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090746"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2010.536795"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1375.002"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1289"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.03.003"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt016"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030686"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533365100"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl057"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021387"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5213"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4730"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1179"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.042"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20812"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.2.306"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030315"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507454102"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4516"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.8.1145"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni743"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2008.62"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200104)31:4<1122::AID-IMMU1122>3.0.CO;2-P"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.32"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000146"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.2.750"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-005660"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015684"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002321"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6150-3-6"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006527"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.016"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.192"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900691"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040249"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050855"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1265"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42945"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804358105"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0882"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.732"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.8.5393"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.04.005"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388546"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070663"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03810.x"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.7350"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0249"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.11.016"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02544.x"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp068"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.12.8059"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.10.010"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12672"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.3105"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1263"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2009.02268.x"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-094656"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636435"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408679102"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811556106"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307185110"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12691"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7259"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041201"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1774"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24219"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.015"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00279-0"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-013-8476-x"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2167"},{"key":"e_1_2_9_217_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-009-8105-x"},{"key":"e_1_2_9_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06797.x"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12581","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:21:49Z","timestamp":1696209709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,8]]},"references-count":217,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/imm.12581"],"URL":"https:\/\/doi.org\/10.1111\/imm.12581","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,8]]},"assertion":[{"value":"2015-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}