{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:28:06Z","timestamp":1787779686633,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"College Scientific Research Project in Guangzhou City","award":["2012C117"],"award-info":[{"award-number":["2012C117"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Schistosoma japonicum<\/jats:italic> infection can induce granulomatous inflammation and cause tissue damage in the mouse liver. The cytokine secretion profile of T helper (Th) cells depends on both the nature of the activating stimulus and the local microenvironment (e.g. cytokines and other soluble factors). In the present study, we found an accumulation of large numbers of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic><jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells in mouse livers. This <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic><jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup> cell population increased from 0\u00b768\u00a0\u00b1\u00a00\u00b757% in uninfected mice to 7\u00b705\u00a0\u00b1\u00a03\u00b70% by week 4 following infection and to 9\u00b76\u00a0\u00b1\u00a05\u00b728% by week 6, before decreasing to 6\u00b73\u00a0\u00b1\u00a05\u00b79% by week 8 in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 T cells. Moreover, <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic><jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup> Th cells were also found in mouse spleen and mesenteric lymph nodes 6\u00a0weeks after infection. The majority of the <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic><jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup> Th cells were thought to be related to a state of immune activation, and some were memory T\u00a0cells. Moreover, we found that these <jats:italic>S.\u00a0japonicum<\/jats:italic> infection\u2010induced <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic><jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup> cells could express interleukin\u20102 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20109, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and high <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 levels at 6\u00a0weeks after <jats:italic>S.\u00a0japonicum<\/jats:italic> infection. Taken together, our data suggest the existence of a population of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic><jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup> plasticity effector\/memory Th cells following <jats:italic>S.\u00a0japonicum<\/jats:italic> infection in C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice.<\/jats:p>","DOI":"10.1111\/imm.12623","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T06:26:38Z","timestamp":1464675998000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Characteristics of <i>Schistosoma japonicum<\/i> infection induced <scp>IFN<\/scp>\u2010<i>\u03b3<\/i> and <scp>IL<\/scp>\u20104 co\u2010expressing plasticity Th cells"],"prefix":"10.1111","volume":"149","author":[{"given":"Dianhui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China"},{"name":"Department of Pathogenic Biology and Immunology Institute of Immunology Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Xie","sequence":"additional","affiliation":[{"name":"Functional Experiment Centre Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefei","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology Institute of Immunology Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology Institute of Immunology Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology Institute of Immunology Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology Institute of Immunology Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sifei","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Immunology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyou","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Immunology Guangzhou China"},{"name":"Key Laboratory of Tropical Disease Control Research of Ministry of Education Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Affiliated No. 8 Guangzhou People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology Institute of Immunology Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(00)00204-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03815.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21060"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017408.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri981"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri843"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000900034"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.4.619"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03289.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/ni.1677","article-title":"IL\u20104 inhibits TGF\u2010\u03b2\u2010induced Foxp3+ T cells and together with TGF\u2010\u03b2, generates IL\u20109+\u00a0IL\u201010+\u00a0Foxp3\u2212 effector T cells","volume":"9","author":"Dardalhon V","year":"2008","journal-title":"Nat Immunol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141557"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.120157"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4080"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071855"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2013.29"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-013-3350-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12105"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.4049\/jimmunol.148.7.2283","article-title":"CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0\u2010like stage","volume":"148","author":"Vella AT","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.4049\/jimmunol.162.7.3882","article-title":"T1\/ST2 expression is enhanced on CD4+ T cells from schistosome egg\u2010induced granulomas: analysis of Th cell cytokine coexpression ex\u00a0vivo","volume":"162","author":"Lohning M","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2013.09.008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001399"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344098"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425027"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001269"},{"key":"e_1_2_8_28_1","first-page":"258","article-title":"Immune response of Th17 cells in mesenteric lymph node of mice infected by Schistosoma japonicum","volume":"30","author":"Luo XP","year":"2012","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"},{"key":"e_1_2_8_29_1","first-page":"449","article-title":"Proportion and characteristics of \u03b3\u03b4T cells in different tissues and organs of C57BL\/6 mice","volume":"29","author":"Huang J","year":"2013","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.4049\/jimmunol.160.11.5280","article-title":"Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL\u20104 and IFN\u2010\u03b3","volume":"160","author":"Miner KT","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0803400"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.12.009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060772"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492010000500011"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.08.003"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1086\/524301"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.011"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.4.f205"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090246"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12623","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:02:39Z","timestamp":1696255359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,11]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/imm.12623"],"URL":"https:\/\/doi.org\/10.1111\/imm.12623","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,11]]},"assertion":[{"value":"2016-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}