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Emerging studies have also reported an altered lipid profile in the early stages of <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>. Our previous works demonstrate that citrate pathway activation is required for oxygen radical production during inflammation. Here, we find up\u2010regulation of the citrate pathway and down\u2010regulation of carnitine\/acylcarnitine carrier and carnitine palmitoyl\u2010transferase 1 genes in cells from children with <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>. Interestingly, when the citrate pathway is inhibited, we observe a reduction in oxygen radicals as well as in lipid peroxidation levels. Our preliminary findings provide evidence for a citrate pathway dysregulation, which could be related to some phenotypic traits of people with <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/imm.12659","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T08:34:45Z","timestamp":1470731685000},"page":"423-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The contribution of the citrate pathway to oxidative stress in Down syndrome"],"prefix":"10.1111","volume":"149","author":[{"given":"Paolo","family":"Convertini","sequence":"first","affiliation":[{"name":"Department of Science University of Basilicata Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Menga","sequence":"additional","affiliation":[{"name":"Department of Biosciences Biotechnology and Pharmacological Sciences University of 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