{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:14:10Z","timestamp":1787498050933,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI072139"],"award-info":[{"award-number":["AI072139"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Preventive influenza vaccines must be reformulated annually because of antigen shift and drift of circulating influenza viral strains. However, seasonal vaccines do not always match the circulating strains, and there is the ever\u2010present threat that avian influenza viruses may adapt to humans. Hence, a universal influenza vaccine is needed to provide protective immunity against a broad range of influenza viruses. We designed an influenza antigen consisting of three tandem M2e repeats plus\n                    <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                    2, in combination with a detoxified anthrax oedema toxin delivery system (\n                    <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>\n                    n plus\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    ) to enhance immune responses. The\n                    <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>\n                    n\u20103\u00d7M2e\u2010\n                    <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                    2 plus\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    vaccine formulation elicited robust, antigen\u2010specific, IgG responses; and was protective against heterologous influenza viral challenge when intranasally delivered to mice three times. Moreover, use of the detoxified anthrax toxin system as an adjuvant had the additional benefit of generating protective immunity against anthrax. Hence, this novel vaccine strategy could potentially address two major emerging public health and biodefence threats.\n                  <\/jats:p>","DOI":"10.1111\/imm.12683","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T07:06:59Z","timestamp":1477292819000},"page":"276-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A dual purpose universal influenza vaccine candidate confers protective immunity against anthrax"],"prefix":"10.1111","volume":"150","author":[{"given":"Maria T.","family":"Ar\u00e9valo","sequence":"first","affiliation":[{"name":"Center of Emphasis in Infectious Diseases Department of Biomedical Sciences Paul L. Foster School of Medicine Texas Tech University Health Sciences Center El Paso El Paso TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Emphasis in Infectious Diseases Department of Biomedical Sciences Paul L. Foster School of Medicine Texas Tech University Health Sciences Center El Paso El Paso TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Diaz\u2010Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"Center of Emphasis in Infectious Diseases Department of Biomedical Sciences Paul L. Foster School of Medicine Texas Tech University Health Sciences Center El Paso El Paso TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Emphasis in Infectious Diseases Department of Biomedical Sciences Paul L. 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