{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:31:18Z","timestamp":1782185478500,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"St Antonius Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Community\u2010acquired pneumonia (<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>) is the leading infectious disease requiring hospitalization in the western world. Genetic variability affecting the host response to infection may play a role in susceptibility and outcome in patients with <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>. Mannose\u2010binding lectin (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>) and <jats:sc>l<\/jats:sc>\u2010ficolin (<jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">FCN<\/jats:styled-content>) are two important activators of the complement system and they can enhance phagocytosis by opsonization. In a prospective cohort of 505 Dutch patients with <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> and 227 control participants we studied whether polymorphisms in the <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic>) and <jats:styled-content style=\"fixed-case\">FCN<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">FCN<\/jats:styled-content>2<\/jats:italic>) genes influenced susceptibility and outcome. No difference in frequency of these genotypes was found between patients with <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> in general and controls. However, the +6424G&gt;T single nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) in <jats:italic><jats:styled-content style=\"fixed-case\">FCN<\/jats:styled-content>2<\/jats:italic> was more common in patients with a <jats:italic>Coxiella burnetii<\/jats:italic> pneumonia (<jats:italic>P<\/jats:italic>\u00a0=<jats:italic>\u00a0<\/jats:italic>0\u00b7014). Moreover, the haplotypes coding for the highest <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> serum levels (<jats:styled-content style=\"fixed-case\">YA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">YA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">YA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">XA<\/jats:styled-content>) predisposed to atypical pneumonia (<jats:italic>C.\u00a0burnetii<\/jats:italic>,<jats:italic> Legionella<\/jats:italic> or <jats:italic>Chlamydia<\/jats:italic> species or <jats:italic>Mycoplasma pneumoniae<\/jats:italic>) compared with controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7016). Furthermore, patients with these haplotypes were more often bacteraemic (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7019). It can therefore be concluded that <jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">FCN<\/jats:styled-content>2<\/jats:italic> polymorphisms are not major risk factors for <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> in general, but that the +6424G&gt;T <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> in the <jats:italic><jats:styled-content style=\"fixed-case\">FCN<\/jats:styled-content>2<\/jats:italic> gene predisposes to <jats:italic>C.\u00a0burnetii<\/jats:italic> pneumonia. In addition, patients with genotypes corresponding with high serum <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> levels are at risk for atypical pneumonia, possibly caused by enhanced phagocytosis, thereby promoting cell entry of these intracellular bacteria.<\/jats:p>","DOI":"10.1111\/imm.12705","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T07:52:46Z","timestamp":1482997966000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Mannose\u2010binding lectin and <scp>l<\/scp>\u2010ficolin polymorphisms in patients with community\u2010acquired pneumonia caused by intracellular pathogens"],"prefix":"10.1111","volume":"151","author":[{"given":"Gijs","family":"van Kempen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine St Antonius Hospital Nieuwegein The Netherlands"},{"name":"Department of Internal Medicine University Medical Centre Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Meijvis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St Antonius Hospital Nieuwegein The Netherlands"},{"name":"Department of Internal Medicine University Medical Centre Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Endeman","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Onze Lieve Vrouwen Gasthuis Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Vlaminckx","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology St Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Meek","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology St Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology St Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ger","family":"Rijkers","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology St Antonius Hospital Nieuwegein The Netherlands"},{"name":"Department of Sciences Roosevelt Academy Middelburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem Jan","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2004.08.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.04.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.143982"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/648678"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2004.10.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03929.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.2.688-693.2000"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.12.8188-8193.2005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/374746"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.6.3013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2005.06.035"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi173"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.1198"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2006.11.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.11.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02634.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02563-5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.08.028"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.04.013"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.05.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/590006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228159"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0642"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.037"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00174111"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/379044"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/340216"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq474"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03975.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08516-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.04.014"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60607-7"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"18939","DOI":"10.2807\/ese.13.31.18939-en","article-title":"Large ongoing Q fever outbreak in the south of The Netherlands, 2008","volume":"13","author":"Schimmer B","year":"2008","journal-title":"Euro Surveill"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03140.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.01.003"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324401"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012669199"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01597-6"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.541"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1086\/431987"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1086\/377183"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12241"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.1800108.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.10.042"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400127"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1785"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:30:02Z","timestamp":1696228202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/imm.12705"],"URL":"https:\/\/doi.org\/10.1111\/imm.12705","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]},"assertion":[{"value":"2016-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}