{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T02:14:36Z","timestamp":1744078476143,"version":"3.37.3"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T00:00:00Z","timestamp":1486598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","award":["PHD\/0167\/2553"],"award-info":[{"award-number":["PHD\/0167\/2553"]}],"id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Burkholderia pseudomallei<\/jats:italic> is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been exposed to the bacteria and have developed some immunity, which may have helped to prevent disease. Here, we used a humanized mouse model (hu\u2010<jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content>), reconstituted with human peripheral blood mononuclear cells from seropositive donors, to illustrate the potential of three known antigens (FliC, OmpA and N\u2010PilO2) for boosting both T\u2010cell and B\u2010cell immune responses. All three antigens boosted the production of specific antibodies <jats:italic>in vivo<\/jats:italic>, and increased the number of antibody and interferon\u2010<jats:italic>\u03b3<\/jats:italic>\u2010secreting cells, and induced antibody affinity maturation. Moreover, antigen\u2010specific antibodies isolated from either seropositive individuals or boosted mice, were found to enhance phagocytosis and oxidative burst activities from human polymorphonuclear cells. Our study demonstrates that FliC, OmpA and N\u2010PilO2 can stimulate human memory T and B cells and highlight the potential of the hu\u2010<jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content> system for screening and evaluation of novel protein antigens for inclusion in future vaccine trials against melioidosis.<\/jats:p>","DOI":"10.1111\/imm.12709","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T07:10:48Z","timestamp":1483945848000},"page":"98-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Boosting of post\u2010exposure human T\u2010cell and B\u2010cell recall responses <i>in vivo<\/i> by <i>Burkholderia pseudomallei<\/i>\u2010related proteins"],"prefix":"10.1111","volume":"151","author":[{"given":"Arnone","family":"Nithichanon","sequence":"first","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise J.","family":"Gourlay","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Bancroft","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ato","sequence":"additional","affiliation":[{"name":"Department of Immunology National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Immunology National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6972-585X","authenticated-orcid":false,"given":"Ganjana","family":"Lertmemongkolchai","sequence":"additional","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1016\/S0035-9203(08)70002-6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.4269\/ajtmh.12-0555"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.4269\/ajtmh.2010.10-0038"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1128\/CMR.18.2.383-416.2005"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.3389\/fcimb.2013.00005"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1371\/journal.pone.0054961"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1093\/bmb\/ldr007"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1086\/313881"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1371\/journal.pntd.0000407"},{"key":"e_1_2_8_11_1","first-page":"25","article-title":"Postexposure prophylaxis for common infectious diseases","volume":"88","author":"Bader MS","year":"2013","journal-title":"Am Fam Physician"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.3389\/fmicb.2011.00198"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.2217\/fmb-2015-0018"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1073\/pnas.0812080106"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1093\/infdis\/jiq142"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1371\/journal.pone.0006496"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1016\/j.vaccine.2016.02.038"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1371\/journal.pntd.0003917"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.4049\/jimmunol.1402273"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1128\/IAI.74.3.1699-1705.2006"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1128\/IAI.64.7.2824-2828.1996"},{"key":"e_1_2_8_22_1","first-page":"187585","article-title":"Towards a rational design of an asymptomatic clinical herpes vaccine: the old, the new, and the unknown","volume":"2012","author":"Chentoufi AA","year":"2012","journal-title":"Clin Dev Immunol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1038\/cmi.2012.2"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1097\/MED.0b013e328337282f"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.1586\/14760584.8.1.113"},{"doi-asserted-by":"publisher","key":"e_1_2_8_26_1","DOI":"10.1038\/nri3311"},{"doi-asserted-by":"publisher","key":"e_1_2_8_27_1","DOI":"10.1038\/nm1431"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.4049\/jimmunol.1201518"},{"doi-asserted-by":"publisher","key":"e_1_2_8_29_1","DOI":"10.1084\/jem.20062411"},{"doi-asserted-by":"publisher","key":"e_1_2_8_30_1","DOI":"10.1128\/JVI.00537-11"},{"doi-asserted-by":"publisher","key":"e_1_2_8_31_1","DOI":"10.1371\/journal.pmed.0050016"},{"doi-asserted-by":"publisher","key":"e_1_2_8_32_1","DOI":"10.1016\/j.virol.2011.05.013"},{"doi-asserted-by":"publisher","key":"e_1_2_8_33_1","DOI":"10.1182\/blood-2008-05-157016"},{"doi-asserted-by":"publisher","key":"e_1_2_8_34_1","DOI":"10.1073\/pnas.1005566107"},{"doi-asserted-by":"publisher","key":"e_1_2_8_35_1","DOI":"10.1038\/cmi.2010.52"},{"doi-asserted-by":"publisher","key":"e_1_2_8_36_1","DOI":"10.1007\/s12185-008-0215-z"},{"doi-asserted-by":"publisher","key":"e_1_2_8_37_1","DOI":"10.1186\/1479-5876-10-30"},{"doi-asserted-by":"publisher","key":"e_1_2_8_38_1","DOI":"10.1038\/icb.2010.151"},{"doi-asserted-by":"publisher","key":"e_1_2_8_39_1","DOI":"10.1016\/j.clim.2004.06.006"},{"doi-asserted-by":"publisher","key":"e_1_2_8_40_1","DOI":"10.4269\/ajtmh.2006.74.330"},{"doi-asserted-by":"publisher","key":"e_1_2_8_41_1","DOI":"10.1371\/journal.pone.0094981"},{"doi-asserted-by":"publisher","key":"e_1_2_8_42_1","DOI":"10.1016\/j.chembiol.2013.07.010"},{"doi-asserted-by":"publisher","key":"e_1_2_8_43_1","DOI":"10.4049\/jimmunol.181.8.5306"},{"doi-asserted-by":"publisher","key":"e_1_2_8_44_1","DOI":"10.1126\/scitranslmed.3002336"},{"key":"e_1_2_8_45_1","first-page":"639","article-title":"Quantitation of immunoglobulin to hepatitis E virus by enzyme immunoassay","volume":"9","author":"Innis BL","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_46_1","DOI":"10.1007\/978-1-59745-324-0_3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_47_1","DOI":"10.1128\/IAI.00503-08"},{"doi-asserted-by":"publisher","key":"e_1_2_8_48_1","DOI":"10.1002\/cyto.a.20859"},{"doi-asserted-by":"publisher","key":"e_1_2_8_49_1","DOI":"10.1016\/1074-7613(95)90066-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_50_1","DOI":"10.1086\/595564"},{"doi-asserted-by":"publisher","key":"e_1_2_8_51_1","DOI":"10.1128\/JB.00378-11"},{"doi-asserted-by":"publisher","key":"e_1_2_8_52_1","DOI":"10.1128\/IAI.00803-10"},{"doi-asserted-by":"publisher","key":"e_1_2_8_53_1","DOI":"10.1371\/journal.pntd.0004152"},{"doi-asserted-by":"publisher","key":"e_1_2_8_54_1","DOI":"10.4049\/jimmunol.166.5.2929"},{"doi-asserted-by":"publisher","key":"e_1_2_8_55_1","DOI":"10.4049\/jimmunol.165.1.518"},{"doi-asserted-by":"publisher","key":"e_1_2_8_56_1","DOI":"10.1084\/jem.175.2.503"},{"doi-asserted-by":"publisher","key":"e_1_2_8_57_1","DOI":"10.1046\/j.1365-2249.2000.01340.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_58_1","DOI":"10.1371\/journal.pone.0013109"},{"doi-asserted-by":"publisher","key":"e_1_2_8_59_1","DOI":"10.1371\/journal.pone.0053495"},{"key":"e_1_2_8_60_1","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.4049\/jimmunol.160.5.2051","article-title":"Antigen\u2010specific IgG responses from naive human splenocytes: in vitro priming followed by antigen boost in the SCID mouse","volume":"160","author":"Brams P","year":"1998","journal-title":"J Immunol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_61_1","DOI":"10.1371\/journal.pntd.0002988"},{"doi-asserted-by":"publisher","key":"e_1_2_8_62_1","DOI":"10.1371\/journal.pone.0052276"},{"doi-asserted-by":"publisher","key":"e_1_2_8_63_1","DOI":"10.1128\/IAI.64.3.782-790.1996"},{"doi-asserted-by":"publisher","key":"e_1_2_8_64_1","DOI":"10.1371\/journal.pone.0017852"},{"doi-asserted-by":"publisher","key":"e_1_2_8_65_1","DOI":"10.1080\/15548627.2015.1040969"},{"doi-asserted-by":"publisher","key":"e_1_2_8_66_1","DOI":"10.1038\/cr.2010.150"},{"doi-asserted-by":"publisher","key":"e_1_2_8_67_1","DOI":"10.1111\/cei.12589"},{"doi-asserted-by":"publisher","key":"e_1_2_8_68_1","DOI":"10.1128\/IAI.00806-12"},{"doi-asserted-by":"publisher","key":"e_1_2_8_69_1","DOI":"10.1186\/s40635-014-0021-2"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:30:26Z","timestamp":1696228226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,9]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/imm.12709"],"URL":"https:\/\/doi.org\/10.1111\/imm.12709","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"type":"print","value":"0019-2805"},{"type":"electronic","value":"1365-2567"}],"subject":[],"published":{"date-parts":[[2017,2,9]]},"assertion":[{"value":"2016-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}