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We show that within the spleens of aged mice antigen capture by\n MZ<\/jats:styled-content>\n B cells, and their ability to shuttle between the follicle and\n MZ<\/jats:styled-content>\n , were impaired. The ability of aged\n MZ<\/jats:styled-content>\n B cells to migrate towards the\n MZ<\/jats:styled-content>\n chemoattractant sphingosine\u20101\u2010phosphate was increased, suggesting that aged\n MZ<\/jats:styled-content>\n B cells had a greater propensity to be retained within the\n MZ<\/jats:styled-content>\n . An extrinsic impairment in aged B\u2010cell migration towards the\n MZ<\/jats:styled-content>\n was demonstrated using bone marrow chimeras. The follicular shuttling of\n MZ<\/jats:styled-content>\n B cells derived from either young or aged bone marrow was similarly reduced in aged recipient spleens, showing that ageing effects on splenic stromal cells were responsible for the impaired follicular shuttling of\n MZ<\/jats:styled-content>\n B cells.\n MZ<\/jats:styled-content>\n B cells rapidly mount T\u2010cell\u2010independent (\n TI<\/jats:styled-content>\n ) antibody\u2010responses to microbial polysaccharide antigen. In aged mice the ability to produce immunoglobulins in response to the\n TI<\/jats:styled-content>\n type 1 antigen\n TNP<\/jats:styled-content>\n \u2010\n LPS<\/jats:styled-content>\n was impaired. These ageing\u2010related changes to the\n MZ<\/jats:styled-content>\n and\n MZ<\/jats:styled-content>\n B cells have implications for the clearance of blood\u2010borne pathogens. Indeed elderly people have increased susceptibility to\n Streptococcus pneumoniae<\/jats:italic>\n , a\n TI<\/jats:styled-content>\n antigen, and decreased responses to vaccination. A thorough analysis of the mechanisms that underpin the ageing\u2010related decline in the status of the\n MZ<\/jats:styled-content>\n and\n MZ<\/jats:styled-content>\n B cells will help the design of novel treatments to improve immunity in the elderly.\n <\/jats:p>","DOI":"10.1111\/imm.12737","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T20:39:54Z","timestamp":1491338394000},"page":"349-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Ageing adversely affects the migration and function of marginal zone B cells"],"prefix":"10.1111","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-2559","authenticated-orcid":false,"given":"Vivian M.","family":"Turner","sequence":"first","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Sciences University of Edinburgh Midlothian UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-1796","authenticated-orcid":false,"given":"Neil A.","family":"Mabbott","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Sciences University of Edinburgh Midlothian UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115728"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1083"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1542"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh142"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5489.89"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05581-11"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.058958-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001271"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12590"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8173"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/hyb.2010.0093"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.4049\/jimmunol.143.10.3200","article-title":"Immaturity of the human splenic marginal zone in infancy. 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