{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T15:01:53Z","timestamp":1780844513464,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Summary<\/jats:title>Regulatory T (Treg) cells play a key role in dampening excessive immune activation. However, antiretroviral therapy (ART<\/jats:styled-content>) \u2010naive HIV<\/jats:styled-content>\u20101 infection maintains the immune system in a sustained state of activation that could alter both Treg cell surface markers and functions. As Treg cell surface markers are directly linked to their functions the overall objective of this study was to determine how ART<\/jats:styled-content>\u2010naive HIV<\/jats:styled-content> infection affects the phenotypic properties of Treg cells. Our data showed that in ART<\/jats:styled-content>\u2010naive HIV<\/jats:styled-content>\u20101 infection, Treg cells are dominated by effector (CD<\/jats:styled-content>45RA<\/jats:styled-content>+<\/jats:sup>\u00a0CD<\/jats:styled-content>27\u2212<\/jats:sup>\u00a0CCR<\/jats:styled-content>7\u2212<\/jats:sup> CD<\/jats:styled-content>62L\u2212<\/jats:sup>) and effector memory (CD<\/jats:styled-content>45RA<\/jats:styled-content>\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>27\u2212<\/jats:sup>\u00a0CCR<\/jats:styled-content>7\u2212<\/jats:sup>\u00a0CD<\/jats:styled-content>62L\u2212<\/jats:sup>) cells. In contrast Treg cells from HIV<\/jats:styled-content>\u2010negative individuals were mainly naive (CD<\/jats:styled-content>45RA<\/jats:styled-content>+<\/jats:sup>\u00a0CD<\/jats:styled-content>27+<\/jats:sup>\u00a0CCR<\/jats:styled-content>7+<\/jats:sup>\u00a0CD<\/jats:styled-content>62L+<\/jats:sup>) and central memory (CD<\/jats:styled-content>45RA<\/jats:styled-content>\u2212<\/jats:sup> CD<\/jats:styled-content>27+<\/jats:sup>\u00a0CCR<\/jats:styled-content>7+<\/jats:sup>\u00a0CD<\/jats:styled-content>62L+<\/jats:sup>) cells. Whereas effector and effector memory Treg cells showed enhanced expression of CD<\/jats:styled-content>39 (P\u00a0<\/jats:italic><\u00a00\u00b705), CD<\/jats:styled-content>73 (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b7001), HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content> and CD<\/jats:styled-content>38 (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b7001); naive and central memory Treg cells showed a significant reduction in the expression of these markers. Overall Treg cell frequencies within total CD<\/jats:styled-content>4+<\/jats:sup> T cells correlated positively with plasmatic HIV<\/jats:styled-content>\u20101 viral load. As increased viral load is associated with augmented CD<\/jats:styled-content>4+<\/jats:sup> T\u2010cell destruction; this could suggest a resistance of peripheral Treg cells to HIV<\/jats:styled-content>\u20101 destruction. Hence the modulation of Treg cell phenotype and frequencies could be considered in designing immunotherapeutic strategies targeting immune system restoration during HIV<\/jats:styled-content>\u20101 infection.<\/jats:p>","DOI":"10.1111\/imm.12738","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:52:31Z","timestamp":1491411151000},"page":"405-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Phenotypic characterization of regulatory T cells from antiretroviral\u2010naive HIV<\/scp>\u20101\u2010infected people"],"prefix":"10.1111","volume":"151","author":[{"given":"Georgia N.","family":"Ambada","sequence":"first","affiliation":[{"name":"Laboratory of Vaccinology\/Biobanking the Chantal Biya International Reference Centre for Research on the Prevention and Management of HIV\/AIDS Yaounde Cameroon"},{"name":"Department of Animal Biology and Physiology Faculty of Sciences 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