{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:13:50Z","timestamp":1791756830541,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007\u20102013"],"award-info":[{"award-number":["FP7\/2007\u20102013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Age affects the immune response to vaccination, with individuals at the extremes of age responding poorly. The initial inflammatory response to antigenic materials shapes the subsequent adaptive response and so understanding is required about the effect of age on the profile of acute inflammatory mediators. In this study we measured the local and systemic inflammatory response after influenza vaccination or infection in neonatal, young adult and aged mice. Mice were immunized intramuscularly with inactivated influenza vaccine with and without the adjuvant <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>59 and then challenged with H1N1 influenza. Age was the major factor affecting the inflammatory profile after vaccination: neonatal mice had more interleukin\u20101<jats:italic>\u03b1<\/jats:italic> (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b1<\/jats:italic>), C\u2010reactive protein (CRP) and granulocyte\u2013macrophage colony\u2010stimulating factor (GMCSF), young adults more tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF), and elderly mice more interleukin\u20101 receptor antagonist (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101RA), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102RA and interferon\u2010<jats:italic>\u03b3<\/jats:italic>\u2010induced protein 10 (IP10). Notably the addition of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>59 induced <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105, granulocyte colony\u2010stimulating factor (G\u2010CSF), Keratinocyte Chemotractant (KC) and monocyte chemoattractant protein 1 (MCP1) in all ages of animals and levels of these cytokines correlated with antibody responses. Age also had an impact on the efficacy of vaccination: neonatal and young adult mice were protected against challenge, but aged mice were not. There were striking differences in the localization of the cytokine response depending on the route of exposure: vaccination led to a high serum response whereas intranasal infection led to a low serum response but a high lung response. In conclusion, we demonstrate that age affects the inflammatory response to both influenza vaccination and infection. These age\u2010induced differences need to be considered when developing vaccination strategies for different age groups.<\/jats:p>","DOI":"10.1111\/imm.12742","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:53:53Z","timestamp":1491411233000},"page":"451-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Inflammatory responses to influenza vaccination at the extremes of age"],"prefix":"10.1111","volume":"151","author":[{"given":"Jacqueline U.","family":"McDonald","sequence":"first","affiliation":[{"name":"Mucosal Infection and Immunity group Section of Virology Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Mucosal Infection and Immunity group Section of Virology Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen T.","family":"Groves","sequence":"additional","affiliation":[{"name":"Mucosal Infection and Immunity group Section of Virology Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-8741","authenticated-orcid":false,"given":"John S.","family":"Tregoning","sequence":"additional","affiliation":[{"name":"Mucosal Infection and Immunity group Section of Virology Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-813"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001977"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis211"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2508"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.09.9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.562495"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1876326X01206010064"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02313-07"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.07.034"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00321"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03159-15"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.02.018"},{"key":"e_1_2_8_14_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"Team R Development Core team","year":"2011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","unstructured":"TangYHM LiW.ggfortify: Unified Interface to Visualize Statistical Result of Popular R Packages. The R Journal2016.","DOI":"10.32614\/RJ-2016-060"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v008.i11"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.2.295"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2075"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.05.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03159-15"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00327-14"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.067"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402071"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2006.11.016"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005368"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.02.012"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00140-6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00240-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-112"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150425"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.08.027"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0303-203"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017919305501"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004384"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00461-09"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.25580"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv052"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S25215"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1519690113"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.07.013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804699105"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.12.090"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400623"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.05.007"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19570"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/909406"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:57:22Z","timestamp":1696255042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/imm.12742"],"URL":"https:\/\/doi.org\/10.1111\/imm.12742","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]},"assertion":[{"value":"2017-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}