{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:14:40Z","timestamp":1791328480977,"version":"4.3.1"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201000009I\u2010003"],"award-info":[{"award-number":["HHSN272201000009I\u2010003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The humanized mouse model has been developed as a model to identify and characterize human immune responses to human pathogens and has been used to better identify vaccine candidates. In the current studies, the humanized mouse was used to determine the ability of a vaccine to affect the immune response to infection with <jats:italic>Mycobacterium tuberculosis<\/jats:italic>. Both human <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells responded to infection in humanized mice as a result of infection. In humanized mice vaccinated with either <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> or with CpG\u2010C, a liposome\u2010based formulation containing the <jats:italic>M. tuberculosis<\/jats:italic> antigen <jats:styled-content style=\"fixed-case\">ESAT<\/jats:styled-content>\u20106, both <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 T cells secreted cytokines that are known to be required for induction of protective immunity. In comparison to the C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mouse model and Hartley guinea pig model of tuberculosis, data obtained from humanized mice complemented the data observed in the former models and provided further evidence that a vaccine can induce a human T\u2010cell response. Humanized mice provide a crucial pre\u2010clinical platform for evaluating human T\u2010cell immune responses in vaccine development against <jats:italic>M. tuberculosis<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/imm.12756","type":"journal-article","created":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T11:17:24Z","timestamp":1494760644000},"page":"150-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Humanized <scp>NOG<\/scp> mice as a model for tuberculosis vaccine\u2010induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis"],"prefix":"10.1111","volume":"152","author":[{"given":"Ajay","family":"Grover","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology &amp; Pathology Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Troy","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology &amp; Pathology Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Rowe","sequence":"additional","affiliation":[{"name":"HuMurine Technologies La Verne CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoLynn M.","family":"Troudt","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology &amp; Pathology Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Creissen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology &amp; Pathology Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology &amp; Pathology Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabal","family":"Banerjee","sequence":"additional","affiliation":[{"name":"HuMurine Technologies La Verne CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerold","family":"Feuer","sequence":"additional","affiliation":[{"name":"HuMurine Technologies La Verne CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3208-2330","authenticated-orcid":false,"given":"Angelo A.","family":"Izzo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology &amp; Pathology Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343815"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a010041"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05775"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1697"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/363732a0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.08.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005049"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.52"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081720"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/644644"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007251"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.10.154"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-145946"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000438"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018045"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02584-08"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005566107"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27249"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001741"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013137"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202810"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-121319"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219985110"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063331"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-14-53"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.09.008"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.01.030"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.10.019"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2012.34"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.21015"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507484102"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052433"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ614"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2243"},{"key":"e_1_2_7_37_1","first-page":"423","article-title":"The role of interleukin\u201012 in acquired immunity to Mycobacterium tuberculosis infection","volume":"84","author":"Cooper AM","year":"1995","journal-title":"Immunology"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2249"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90001-2"},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.4049\/jimmunol.155.5.2515","article-title":"IL\u201012 increases resistance of BALB\/c mice to Mycobacterium tuberculosis infection","volume":"155","author":"Flynn JL","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2016.05.006"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1211"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.11.6.1174-1181.1975"},{"key":"e_1_2_7_44_1","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.4049\/jimmunol.158.4.1949","article-title":"Human T cell responses induced by vaccination with Mycobacterium bovis bacillus Calmette\u2013Gu\u00e9rin","volume":"158","author":"Ravn P","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.2.294-309.2002"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12480"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.02.009"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200839148"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.570-575.2004"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.6.1723"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0207"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.05.050"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040455"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838693"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00624-07"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00434"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.TBTB2\u20100007\u20102016"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1086\/313885"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2008.00303.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0496-430"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trivac.2014.02.001"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12258"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:06:52Z","timestamp":1696252012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,19]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/imm.12756"],"URL":"https:\/\/doi.org\/10.1111\/imm.12756","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,19]]},"assertion":[{"value":"2017-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}