{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:21:04Z","timestamp":1792095664181,"version":"4.4.0"},"reference-count":96,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Type 2 diabetes mellitus(\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    ) is a major risk factor for the development of active pulmonary tuberculosis (\n                    <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>\n                    ), with development of\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    pandemic in countries where\n                    <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>\n                    is also endemic. Understanding the impact of\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    on\n                    <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>\n                    and the determinants of co\u2010morbidity is essential in responding to this growing public health problem with improved therapeutic approaches. Despite the clinical and public health significance posed by the dual burden of\n                    <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    , little is known about the immunological and biochemical mechanisms of susceptibility. One possible mechanism is that an impaired immune response in patients with DM facilitates either primary infection with\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    or reactivation of latent\n                    <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>\n                    . Diabetes is associated with immune dysfunction and alterations in the components of the immune system, including altered levels of specific cytokines and chemokines. Some effects of DM on adaptive immunity that are potentially relevant to\n                    <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>\n                    defence have been identified in humans. In this review, we summarize current findings regarding the alterations in the innate and adaptive immune responses and immunological mechanisms of susceptibility of patients with\n                    <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                    to\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    infection and disease.\n                  <\/jats:p>","DOI":"10.1111\/imm.12762","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T19:32:03Z","timestamp":1495567923000},"page":"13-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":188,"title":["Influence of diabetes mellitus on immunity to human tuberculosis"],"prefix":"10.1111","volume":"152","author":[{"given":"Pavan","family":"Kumar Nathella","sequence":"first","affiliation":[{"name":"National Institutes of Health\u2014International Centre for Excellence in Research Chennai India"},{"name":"National Institute for Research in Tuberculosis Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-8042","authenticated-orcid":false,"given":"Subash","family":"Babu","sequence":"additional","affiliation":[{"name":"National Institutes of Health\u2014International Centre for Excellence in Research Chennai India"},{"name":"Laboratory of Parasitic Diseases National Institutes of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70282-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050152"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-81"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041367"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046502"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344301"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-9792(13)70004-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.7.1584"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01397.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.14"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051058"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.144.7.2771"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2012.10.003"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12496"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2016.10.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-9792(13)70015-5"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1054\/tuld.1998.0167"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.11.013"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117941"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1799"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052545"},{"key":"e_1_2_11_23_1","first-page":"349","article-title":"Localization of T cells, macrophages and dendritic cells in rat respiratory tract tissue: implications for immune function studies","volume":"62","author":"Holt PG","year":"1987","journal-title":"Immunology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.2.436"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12632"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.10.003"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1744-1753.2005"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110919"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.03.017"},{"key":"e_1_2_11_31_1","first-page":"299","article-title":"Functional state analysis of phagocytic cells of patients with type 2 diabetes and pulmonary tuberculosis","volume":"58","author":"Mendoza\u2010Aguilar M","year":"2012","journal-title":"Clin Lab"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600019"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2011.07.008"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-9792(09)70018-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12421"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21782"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01515-08"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1267"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2016.05.007"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.29"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.03.027"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132703"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00702.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2243"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.1.39"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2249"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1449"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101377"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.13"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1086\/590565"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit241"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201305-112OC"},{"key":"e_1_2_11_54_1","first-page":"179","article-title":"The sensitivity of interferon\u2010gamma release assays is not compromised in tuberculosis patients with diabetes","volume":"15","author":"Walsh MC","year":"2011","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00226613"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0395-0"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2014.885657"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2274"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095939"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402244"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104635"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit241"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02184.x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu329"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545973"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0490-8"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.001"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv484"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09247"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.10.029"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-009-0032-7"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir939"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70015-X"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001269"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112108"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178000"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1799"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.08.021"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1937"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031005"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.12.026"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.6.3695"},{"key":"e_1_2_11_85_1","first-page":"213","article-title":"Role of IL\u201022 in microbial host defense","volume":"380","author":"Eidenschenk C","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.007"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.06.004"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0427"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01767-4"},{"key":"e_1_2_11_90_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/iai.28.1.127-131.1980","article-title":"Depressed immunological defence mechanisms in mice with experimentally induced diabetes","volume":"28","author":"Saiki O","year":"1980","journal-title":"Infect Immun"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0478OC"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000304"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401125"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw436"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2016.12.002"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005972"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.12.015"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:07:10Z","timestamp":1696237630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,29]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/imm.12762"],"URL":"https:\/\/doi.org\/10.1111\/imm.12762","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,29]]},"assertion":[{"value":"2017-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}