{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:37:35Z","timestamp":1790649455145,"version":"4.1.0"},"reference-count":96,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471552"],"award-info":[{"award-number":["81471552"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1408085MH156"],"award-info":[{"award-number":["1408085MH156"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>\u03b3\u03b4<\/jats:italic>\n                    T cells are greatly enriched in mucosal and epithelial sites, such as the skin, respiratory, digestive and reproductive tracts, and they are defined as tissue\u2010resident immune cells. In these tissues, the characteristics and biological roles of\n                    <jats:italic>\u03b3\u03b4<\/jats:italic>\n                    T cells are distinguished from each other. The lungs represent the most challenging immunological dilemma for the host, and they have their own effective immune system. The abundance of\n                    <jats:italic>\u03b3\u03b4<\/jats:italic>\n                    T cells, an estimated 8\u201320% of resident pulmonary lymphocytes in the lung, maintains lung tissue homeostasis. In this review, we summarize the recent research progress regarding lung\u2010resident\n                    <jats:italic>\u03b3\u03b4<\/jats:italic>\n                    T cells, including their development, residency and immune characteristics, and discuss the involvement of\n                    <jats:italic>\u03b3\u03b4<\/jats:italic>\n                    T cells in infectious diseases of the lung, including bacterial, viral and fungal infections; lung allergic disease; lung inflammation and fibrosis; and lung cancer.\n                  <\/jats:p>","DOI":"10.1111\/imm.12764","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T01:56:50Z","timestamp":1496023010000},"page":"375-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Lung\u2010resident\n                    <i>\u03b3\u03b4<\/i>\n                    T cells and their roles in lung diseases"],"prefix":"10.1111","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-8365","authenticated-orcid":false,"given":"Min","family":"Cheng","sequence":"first","affiliation":[{"name":"Gerontology Institute of Anhui Province Anhui Province Hospital Anhui Medical University Hefei China"},{"name":"Anhui Provincial Key Laboratory of Tumour Immunotherapy and Nutrition Therapy Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilian","family":"Hu","sequence":"additional","affiliation":[{"name":"Gerontology Institute of Anhui Province Anhui Province Hospital Anhui Medical University Hefei China"},{"name":"Anhui Provincial Key Laboratory of Tumour Immunotherapy and Nutrition Therapy Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2781"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12495"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri797"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90139-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06355.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2012.00435.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.1710"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939922"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1717"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204327109"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.11.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6217-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/322836a0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00478.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.10.163"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/340239a0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/343754a0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/6.9.1287"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0505244"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.94"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1412058112"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/375155a0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00575"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.42"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.4.519"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039750"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12043"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737216"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.11.015"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4A0315-115RR"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2149"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4662"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903332"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2008.25"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2013.05.001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000789"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601024"},{"key":"e_1_2_7_39_1","first-page":"1","article-title":"Respective 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