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It consists of the TCR\u2010\n                    <jats:italic>\u03b1\u03b2<\/jats:italic>\n                    heterodimer and the non\u2010covalently associated signalling dimers of CD3\n                    <jats:italic>\u03b5\u03b3<\/jats:italic>\n                    , CD3\n                    <jats:italic>\u03b5\u03b4<\/jats:italic>\n                    and CD3\n                    <jats:italic>\u03b6\u03b6<\/jats:italic>\n                    . TCR\u2010\n                    <jats:italic>\u03b1\u03b2<\/jats:italic>\n                    binds specifically to a cognate peptide antigen bound to an MHC molecule, whereas the CD3 subunits transmit the signal into the cytosol to activate signalling events. Recruitment of proteins to specialized localizations is one mechanism to regulate activation and termination of signalling. In the last 25\u00a0years a large number of signalling molecules recruited to the TCR\u2013CD3 complex upon antigen binding to TCR\u2010\n                    <jats:italic>\u03b1\u03b2<\/jats:italic>\n                    have been described. Here, we review knowledge about five of those interaction partners: Lck, ZAP\u201070, Nck, WASP and Numb. Some of these proteins have been targeted in the development of immunomodulatory drugs aiming to treat patients with autoimmune diseases and organ transplants.\n                  <\/jats:p>","DOI":"10.1111\/imm.12809","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T15:41:42Z","timestamp":1501774902000},"page":"42-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Selected signalling proteins recruited to the T\u2010cell receptor\u2013CD3 complex"],"prefix":"10.1111","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3762-3872","authenticated-orcid":false,"given":"Jatuporn","family":"Ngoenkam","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology Faculty of Medical Science Naresuan University Phitsanulok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang 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