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The roles of these immune components are not yet characterized for the autoimmune skin disorder Pemphigus vulgaris (PV). Phenotyping and frequency of <jats:italic>\u03b3\u03b4<\/jats:italic> T cells estimated by flow cytometry have shown increased frequency of <jats:italic>\u03b3\u03b4<\/jats:italic> T cells (6\u00b77% versus 4\u00b74%) producing interferon\u2010 <jats:italic>\u03b3<\/jats:italic> (IFN\u2010<jats:italic>\u03b3<\/jats:italic>; 35\u00b72% versus 26\u00b768%) in the circulation of patients compared with controls. Dual cytokine\u2010secreting (IFN\u2010<jats:italic>\u03b3<\/jats:italic> and interleukin\u20104) <jats:italic>\u03b3\u03b4<\/jats:italic> T cells indicate the plasticity of these cells. The <jats:italic>\u03b3\u03b4<\/jats:italic> T cells of patients with PV have shown higher cytotoxic potential and the higher frequency of <jats:italic>\u03b3\u03b4<\/jats:italic> T cells producing IFN\u2010<jats:italic>\u03b3<\/jats:italic> shows T helper type 1 polarization. The increased expression of Scavenger receptors expression (CD36 and CD163) could be contributing to the elevated inflammatory environment and immune imbalance in this disease. Targeting the inflammatory <jats:italic>\u03b3\u03b4<\/jats:italic> T cells and Scavenger receptors may pave the way for novel therapeutics.<\/jats:p>","DOI":"10.1111\/imm.12814","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T07:55:48Z","timestamp":1502956548000},"page":"97-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["T helper type 1 polarizing <i>\u03b3\u03b4<\/i> T cells and Scavenger receptors contribute to the pathogenesis of Pemphigus vulgaris"],"prefix":"10.1111","volume":"153","author":[{"given":"Dayasagar","family":"Das","sequence":"first","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujay","family":"Khandpur","sequence":"additional","affiliation":[{"name":"Department of Dermatology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Dermatology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-5511","authenticated-orcid":false,"given":"Alpana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"8","article-title":"Pemphigus Vulgaris: gingival involvement. 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