{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:03:01Z","timestamp":1769101381683,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of University","award":["Bando 2015 Prot. 20157ATSLF"],"award-info":[{"award-number":["Bando 2015 Prot. 20157ATSLF"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Natural killer (NK) cells provide a major defence against human cytomegalovirus (HCMV) infection through the interaction of their surface receptors, including the activating and inhibitory killer immunoglobulin\u2010like receptors (KIRs), and human leucocyte antigen (HLA) class I molecules. Also <jats:italic>\u03b3<\/jats:italic> marker (GM) allotypes, able to influence the NK antibody\u2010dependent cell\u2010mediated cytotoxicity, appear to be involved in the immunological control of virus infections, including HCMV. In some cases, their contribution requires epistatic interaction with other genes of the immune system, such as HLA. In the present report, with the aim of gaining insight into the immune mechanisms controlling HCMV, we have studied the possible associations among humoral and NK responses, and HCMV infections. In a previous study we assessed whether the KIR and HLA repertoire might influence the risk of developing symptomatic (<jats:italic>n<\/jats:italic> = 60) or asymptomatic (<jats:italic>n<\/jats:italic> = 60) disease after primary HCMV infection in the immunocompetent host. In the present study, the immunocompetent patients with primary symptomatic HCMV infection were genotyped for GM3\/17 and GM23 allotypes, along with the 60 participants with a previous asymptomatic infection as controls. Notwithstanding the presence of missing data record, advanced missing data recovery techniques were able to show that individuals carrying the GM23 allotypes, both homozygous and heterozygous, GM17\/17, HLA\u2010C2 and Bw4<jats:sup>T<\/jats:sup> KIR\u2010ligand groups are associated with the risk of developing symptomatic infection. Our findings on the role of both cellular and humoral immunity in the control of HCMV infection should be of value in guiding efforts to reduce HCMV\u2010associated health complications in the elderly, including immunosenescence, and in transplantation.<\/jats:p>","DOI":"10.1111\/imm.12855","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T08:26:40Z","timestamp":1508920000000},"page":"523-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association between <i>\u03b3<\/i> marker, human leucocyte antigens and killer immunoglobulin\u2010like receptors and the natural course of human cytomegalovirus infection: a pilot study performed in a Sicilian population"],"prefix":"10.1111","volume":"153","author":[{"given":"Danilo","family":"Di Bona","sequence":"first","affiliation":[{"name":"Dipartimento dell'Emergenza e dei Trapianti d'Organo Universit\u00e0 di Bari Aldo Moro Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Accardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Aiello","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Bilancia","sequence":"additional","affiliation":[{"name":"Dipartmento Jonico in Sistemi Giuridici ed Economici del Mediterraneo: societ\u00e0, ambiente, culture Universit\u00e0 di Bari Aldo Moro Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Candore","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Colomba","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze per la Promozione della Salute e Materno\u2010Infantile \u201cG. D'Alessandro\u201d Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8004-2363","authenticated-orcid":false,"given":"Calogero","family":"Caruso","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Duro","sequence":"additional","affiliation":[{"name":"Istituto di Biomedicina e Immunologia Molecolare Consiglio Nazionale delle Ricerche Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina M.","family":"Gambino","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Macchia","sequence":"additional","affiliation":[{"name":"Dipartimento dell'Emergenza e dei Trapianti d'Organo Universit\u00e0 di Bari Aldo Moro Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janardan P.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Medical University of South Carolina Charleston USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6062242"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-9-23"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-015-0056-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03489-14"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.10.027"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-157354"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01096-13"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1526"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906293202605"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374279-7.14006-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.10.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/592282"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500872"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu226"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu367"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2016.11.003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.28609"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1201\/b11826","volume-title":"Flexible Imputation of Missing Data","author":"Van Buuren S","year":"2012"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116164"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780141205"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2016.57.321"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03519.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00236"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.11.004"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.17.8596-8608.2002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004131"},{"key":"e_1_2_8_31_1","first-page":"907","article-title":"The human cytomegalovirus TRL11\/IRL11\u2010encoded Fc\u03b3R binds differentially to allelic variants of immunoglobulin G1 Arch","volume":"156","author":"Namboodiri A","year":"2011","journal-title":"Virol"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.09.005"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200009)30:9<2540::AID-IMMU2540>3.0.CO;2-S"},{"key":"e_1_2_8_34_1","first-page":"91","volume-title":"Updates in Pathobiology: Causality and Chance in Ageing, Age\u2010Related Diseases and Longevity","author":"Aiello A","year":"2017"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21187"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374279-7.19003-4"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:41:26Z","timestamp":1695685286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/imm.12855"],"URL":"https:\/\/doi.org\/10.1111\/imm.12855","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]},"assertion":[{"value":"2017-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}