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Parasite\u2010mediated immune suppression is a hallmark triggering infection outcome in both chronic human and murine <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>. So far, little is known about secondary systemic immune effects of this pathogen on other concomitant diseases,\u00a0e.g. endogenous gut inflammation. We examined the influence of <jats:italic>E.\u00a0multilocularis<\/jats:italic> infection on murine dextran sodium sulphate (<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>) \u2010induced colitis. At 3\u00a0months after <jats:italic>E.\u00a0multilocularis<\/jats:italic> infection (chronic stage), the mice were challenged with 3% <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> in the drinking water for 5\u00a0days plus subsequently with tap water (alone) for another 4\u00a0days. After necropsy, fixed tissues\/organs were sectioned and stained with haematoxylin &amp; eosin for assessing inflammatory reactions. Cytokine levels were measured by flow cytometry and quantitative <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Colitis severity was assessed (by board\u2010certified veterinary pathologists) regarding (i) colon length, (ii) weight loss and (iii) a semi\u2010quantitative score of morphological changes. The histopathological analysis of the colon showed a significant reduction of <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010induced gut inflammation by concomitant <jats:italic>E.\u00a0multilocularis<\/jats:italic> infection, which correlated with down\u2010regulation of T helper type 1 (Th1)\/Th17 T\u2010cell responses in the colon tissue. <jats:italic>Echinococcus multilocularis<\/jats:italic> infection markedly reduced the severity of <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010induced gut inflammation upon down\u2010regulation of Th1\/Th17 cytokine expression and attenuation of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b<jats:sup>+<\/jats:sup> cell activation. In conclusion, <jats:italic>E.\u00a0multilocularis<\/jats:italic> infection remarkably reduces <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010induced colitis in mice by attenuating Th1\/Th17\u2010mediated immune reactions.<\/jats:p>","DOI":"10.1111\/imm.12860","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T18:42:38Z","timestamp":1510252958000},"page":"76-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Larval <i>Echinococcus multilocularis<\/i> infection reduces dextran sulphate sodium\u2010induced colitis in mice by attenuating T helper type 1\/type 17\u2010mediated immune reactions"],"prefix":"10.1111","volume":"154","author":[{"given":"Junhua","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Pathobiology Vetsuisse Faculty Institute of Parasitology University of Bern Bern 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