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In particular, high\u2010throughput B\u2010cell receptor (<jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>) repertoire sequencing provides detailed information about the functionality and abnormalities of the B\u2010cell system. However, it is mostly unknown how the <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content> repertoire is altered in the context of primary immunodeficiencies (<jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>) and whether findings are consistent throughout phenotypes and genotypes. We have performed an extensive literature search of the published work on <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content> repertoire sequencing in <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> patients, including several forms of predominantly antibody disorders and combined immunodeficiencies. It is somewhat surprising that <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content> repertoires, even from severe clinical phenotypes, often show only mild abnormalities and that diversity or immunoglobulin gene segment usage is generally preserved to some extent. Despite the great variety of wet laboratory and analytical methods that were used in the different studies, several findings are common to most investigated <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>s, such as the increased usage of gene segments that are associated with self\u2010reactivity. These findings suggest that <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content> repertoire characteristics may be used to assess the functionality of the B\u2010cell compartment irrespective of the underlying defect. With the use of <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content> approaches, there is now the opportunity to apply <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content> repertoire sequencing to multiple patients and explore the <jats:styled-content style=\"fixed-case\">PID BCR<\/jats:styled-content> repertoire in more detail. Ultimately, using <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content> repertoire sequencing in translational research could aid the management of <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> patients by improving diagnosis, estimating functionality of the immune system and improving assessment of prognosis.<\/jats:p>","DOI":"10.1111\/imm.12865","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T13:58:37Z","timestamp":1510754317000},"page":"145-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["B\u2010cell receptor repertoire sequencing in patients with primary immunodeficiency: a review"],"prefix":"10.1111","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7348-796X","authenticated-orcid":false,"given":"Marie","family":"Ghraichy","sequence":"first","affiliation":[{"name":"Division of Immunology University Children's Hospital Zurich Zurich Switzerland"},{"name":"Children's Research Center University Children's Hospital University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4916-800X","authenticated-orcid":false,"given":"Jacob D.","family":"Galson","sequence":"additional","affiliation":[{"name":"Children's Research Center University Children's Hospital University of Zurich Zurich Switzerland"},{"name":"University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic F.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group Department of Paediatrics University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-7381","authenticated-orcid":false,"given":"Johannes","family":"Tr\u00fcck","sequence":"additional","affiliation":[{"name":"Division of Immunology University Children's Hospital Zurich Zurich Switzerland"},{"name":"Children's Research Center University Children's Hospital University of Zurich Zurich Switzerland"},{"name":"University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241146"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01955.x"},{"key":"e_1_2_8_4_1","volume-title":"The generation of diversity in immunoglobulins Virtually. 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