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Myriad genetic, immunological and environmental factors may contribute to an individual's susceptibility to neurological disease. Here, we review and discuss the decades long research on the influence of genetic variation at the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\n                    <\/jats:italic>\n                    locus and the role of immunogenetic killer cell immunoglobulin\u2010like receptor (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content>\n                    <\/jats:italic>\n                    ) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. The findings of immunogenetic association studies are consistent with a polygenic model of inheritance in the heterogeneous and multifactorial nature of complex traits in various neurological diseases. Future investigation is highly recommended to evaluate both coding and non\u2010coding variation in immunogenetic loci using high\u2010throughput high\u2010resolution next\u2010generation sequencing technologies in diverse ethnic groups to fully appreciate their role in neurological diseases.\n                  <\/jats:p>","DOI":"10.1111\/imm.12869","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T02:42:38Z","timestamp":1511232158000},"page":"399-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["The immunogenetics of neurological disease"],"prefix":"10.1111","volume":"153","author":[{"given":"Maneesh K.","family":"Misra","sequence":"first","affiliation":[{"name":"Department of Neurology San Francisco School of Medicine University of California San Francisco CA 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