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Exposure of primary murine dermal microvascular endothelial cells (pDMEC<\/jats:styled-content>s) toNE<\/jats:styled-content>followed by co\u2010culture with Langerhans cells (LC<\/jats:styled-content>s), responsiveCD<\/jats:styled-content>4+<\/jats:sup>T\u2010cells and antigen resulted in modulation ofCD<\/jats:styled-content>4+<\/jats:sup>T\u2010cell responses.NE<\/jats:styled-content>\u2010treatment ofpDMEC<\/jats:styled-content>s induced increased production of interleukin (IL<\/jats:styled-content>)\u20106 andIL<\/jats:styled-content>\u201017A while down\u2010regulating interferon (IFN<\/jats:styled-content>)\u2010\u03b3<\/jats:italic>andIL<\/jats:styled-content>\u201022 release. This effect did not require contact betweenpDMEC<\/jats:styled-content>s andLC<\/jats:styled-content>s or T\u2010cells and depended uponpDMEC<\/jats:styled-content>production ofIL<\/jats:styled-content>\u20106. The presence ofNE<\/jats:styled-content>\u2010treatedpDMEC<\/jats:styled-content>s increased the proportion ofCD<\/jats:styled-content>4+<\/jats:sup>T\u2010cells expressing intracellularIL<\/jats:styled-content>\u201017A and increasedIL<\/jats:styled-content>\u201017AmRNA<\/jats:styled-content>while decreasing the proportion ofIFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic>\u2010 orIL<\/jats:styled-content>\u201022\u2010expressingCD<\/jats:styled-content>4+<\/jats:sup>T\u2010cells andmRNA<\/jats:styled-content>levels for those cytokines. Retinoic acid receptor\u2010related orphan receptor gamma (ROR\u2010<\/jats:styled-content>\u03b3<\/jats:italic>t)mRNA<\/jats:styled-content>was significantly increased inCD<\/jats:styled-content>4+<\/jats:sup>T\u2010cells while T\u2010box transcription factor (T\u2010bet)mRNA<\/jats:styled-content>was decreased. Intradermal administration ofNE<\/jats:styled-content>prior to hapten immunization at the injection site produced a similar bias in draining lymph nodeCD<\/jats:styled-content>4+<\/jats:sup>T\u2010cells towardsIL<\/jats:styled-content>\u201017A and away fromIFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic>andIL<\/jats:styled-content>\u201022 production. Under stress, release ofNE<\/jats:styled-content>may have significant regulatory effects on the outcome of antigen presentation through actions onEC<\/jats:styled-content>s with enhancement of inflammatory skin disorders involving IL\u201017\/T helper type 17 (Th17) cells.<\/jats:p>","DOI":"10.1111\/imm.12871","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T01:56:43Z","timestamp":1511315803000},"page":"104-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of T helper cell responses during antigen presentation by norepinephrine\u2010exposed endothelial cells"],"prefix":"10.1111","volume":"154","author":[{"given":"Linghui","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology Weill Cornell Medicine New York NY 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