{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:48:55Z","timestamp":1762102135101,"version":"3.41.0"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Zika virus (<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>), a single\u2010stranded<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>virus of the Flaviviridae family, is an arbovirus (viruses transmitted by arthropods) transmitted to humans and non\u2010human primates through the bites of infected female<jats:italic>Aedes<\/jats:italic>sp. mosquitoes. Although first isolated in 1947, it only recently emerged as a global threat, present in several countries resulting in a pandemic scenario.<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>infections may have severe outcomes, such as neurological impairment, and with the intrinsic ability of inducing microcephaly in fetuses of infected pregnant women, the virus has become a major public health problem. This review discusses some advances in diagnosis; vaccine development and the problems associated with their administration; the importance of the cross\u2010reactivity with other flaviviruses in protecting or worsening the disease; the implications of the recent outbreak caused by the virus in the world; and future prospects for the complete understanding of this disease.<\/jats:p>","DOI":"10.1111\/imm.12878","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T10:55:42Z","timestamp":1513421742000},"page":"435-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Current priorities in the Zika response"],"prefix":"10.1111","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-4471","authenticated-orcid":false,"given":"Danillo L. A.","family":"Esposito","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan B.","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Graduate Studies Programme on Basic and Applied Immunology Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-5687","authenticated-orcid":false,"given":"Benedito","family":"Ant\u00f4nio Lopes da Fonseca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(52)90042-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(54)90006-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2102.141363"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0332"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.14.20761"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13681"},{"key":"e_1_2_9_8_1","first-page":"712","volume-title":"Fields Virology","author":"Lindenbach BD","year":"2013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001477"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6539e1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.4741"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20165420"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1001\/jama.2016.19328","article-title":"First inactivated Zika vaccine trial","volume":"316","author":"Abbasi J","year":"2016","journal-title":"JAMA"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4322"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1001\/jama.2016.15862","article-title":"DNA vaccine protects monkeys against Zika virus infection","volume":"316","author":"Hampton T","year":"2016","journal-title":"JAMA"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14072"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4364-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805715"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2014.04.008"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004726"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.351.6280.1377"},{"volume-title":"Boletim epidemiol\u00f3gico","year":"2017","author":"Sa\u00fade Md","key":"e_1_2_9_22_1"},{"key":"e_1_2_9_23_1","unstructured":"WHO(ed.). (2017)Zika virus \u2013 Situation Report 5.http:\/\/apps.who.int\/iris\/bitstream\/10665\/254714\/1\/zikasitrep10Mar17-eng.pdf?ua=1[accessed on 4 July 2017]."},{"key":"e_1_2_9_24_1","first-page":"525","article-title":"Possible roles of new mutations shared by Asian and American Zika Viruses","volume":"34","author":"Yokoyama S","year":"2017","journal-title":"Mol Biol Evol"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00032-16"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6503e1"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.05.012"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6521e1"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0267"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1603618"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3899"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600651"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.3720"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30844-3"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/cid\/ciw476","article-title":"Zika virus infection associated with severe thrombocytopenia","volume":"63","author":"Sharp TM","year":"2016","journal-title":"Clin Infect Dis"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.15844\/pedneurbriefs-30-1-7"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1605367"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00651-6"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"e_1_2_9_40_1","first-page":"S1","article-title":"Major birth defects data from population\u2010based birth defects surveillance programs in the United States, 2006\u20102010","volume":"97","author":"CDC. National Birth Defects Prevention Network","year":"2013","journal-title":"Birth Defects Res Part A Clin Mol Teratol"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.17-11-386"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.452"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67665-9"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-007-0022-6"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000344"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.9.20720"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.20344\/amp.6929"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003257"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1609015"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00562-6"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9505"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.32.30314"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2301.161300"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30193-1"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.079"},{"key":"e_1_2_9_56_1","unstructured":"World Health Organization (WHO). (2016)Prevention of sexual transmission of Zika virus: interim guidance update.http:\/\/apps.who.int\/iris\/bitstream\/10665\/204421\/1\/WHO_ZIKV_MOC_16.1_eng.pdf. URL [accessed on 29 June 2017]."},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.06.003"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006164"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.04.019"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006184"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601949"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2017.06.019"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix558"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3849"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T22:16:04Z","timestamp":1751148964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,2]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/imm.12878"],"URL":"https:\/\/doi.org\/10.1111\/imm.12878","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"type":"print","value":"0019-2805"},{"type":"electronic","value":"1365-2567"}],"subject":[],"published":{"date-parts":[[2018,1,2]]},"assertion":[{"value":"2017-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}