{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:02:17Z","timestamp":1789981337823,"version":"4.0.1"},"reference-count":78,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Zika virus (<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>) is responsible for a recent global epidemic that has been associated with congenital brain malformations in fetuses and with Guillain\u2013Barr\u00e9 syndrome in adults. Within the last 2\u00a0years, a major effort has been made to develop murine models to study the mechanism of viral transmission, pathogenesis and the host immune response. Here, we discuss the findings from these models regarding the role that the innate and adaptive immune responses have in controlling <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection and pathogenesis. Additionally, we examine how innate and adaptive immune responses influence sexual and vertical transmission of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection as well as how these responses can influence the ability of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> to cross the placenta and to induce damage in the developing brain.<\/jats:p>","DOI":"10.1111\/imm.12883","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T10:19:25Z","timestamp":1513765165000},"page":"443-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Using immunocompromised mice to identify mechanisms of Zika virus transmission and pathogenesis"],"prefix":"10.1111","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-3378","authenticated-orcid":false,"given":"Clayton W.","family":"Winkler","sequence":"first","affiliation":[{"name":"Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases Hamilton MT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4177-7249","authenticated-orcid":false,"given":"Karin E.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases Hamilton MT 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