{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:53:52Z","timestamp":1779177232753,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["136781"],"award-info":[{"award-number":["136781"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Summary<\/jats:title>Persistent viruses evade immune detection by interfering with virus\u2010specific innate and adaptive antiviral immune responses. Fibrinogen\u2010like protein\u20102 (FGL<\/jats:styled-content>2) is a potent effector molecule of CD<\/jats:styled-content>4+<\/jats:sup>\u00a0CD<\/jats:styled-content>25+<\/jats:sup>\u00a0FoxP3+<\/jats:sup> regulatory T cells and exerts its immunosuppressive activity following ligation to its cognate receptor, Fc\u03b3<\/jats:italic>RIIB<\/jats:styled-content>\/RIII<\/jats:styled-content>. The role of FGL<\/jats:styled-content>2 in the pathogenesis of chronic viral infection caused by lymphocytic choriomeningitis virus clone\u201013 (LCMV<\/jats:styled-content> cl\u201013) was assessed in this study. Chronically infected fgl2<\/jats:italic>+\/+<\/jats:sup> mice had increased plasma levels of FGL<\/jats:styled-content>2, with reduced expression of the maturation markers, CD<\/jats:styled-content>80, CD<\/jats:styled-content>86 and MHC<\/jats:styled-content>\u2010II<\/jats:styled-content> on macrophages and dendritic cells and impaired production of neutralizing antibody. In contrast, fgl2<\/jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice or fgl2<\/jats:italic>+\/+<\/jats:italic><\/jats:sup> mice that had been pre\u2010treated with antibodies to FGL<\/jats:styled-content>2 and Fc\u03b3<\/jats:italic>RIIB<\/jats:styled-content>\/RIII<\/jats:styled-content> and then infected with LCMV<\/jats:styled-content> cl\u201013 developed a robust CD<\/jats:styled-content>4+<\/jats:sup> and CD<\/jats:styled-content>8+<\/jats:sup> antiviral T\u2010cell response, produced high titred neutralizing antibody to LCMV<\/jats:styled-content> and cleared LCMV<\/jats:styled-content>. Treatment of mice with established chronic infection with antibodies to FGL<\/jats:styled-content>2 and Fc\u03b3<\/jats:italic>RIIB<\/jats:styled-content>\/RIII<\/jats:styled-content> was shown to rescue the number and functionality of virus\u2010specific CD<\/jats:styled-content>4+<\/jats:sup> and CD<\/jats:styled-content>8+<\/jats:sup> T cells with reduced total and virus\u2010specific T\u2010cell expression of programmed cell death protein 1 leading to viral clearance. These results demonstrate an important role for FGL<\/jats:styled-content>2 in viral immune evasion and provide a rationale to target FGL<\/jats:styled-content>2 to treat patients with chronic viral infection.<\/jats:p>","DOI":"10.1111\/imm.12897","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T13:32:34Z","timestamp":1516195954000},"page":"476-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inhibition of the Fibrinogen\u2010Like Protein 2:Fc\u03b3<\/i>RIIB<\/scp>\/RIII<\/scp> immunosuppressive pathway enhances antiviral T\u2010cell and B\u2010cell responses leading to clearance of lymphocytic choriomeningitis virus clone 13"],"prefix":"10.1111","volume":"154","author":[{"given":"Olga","family":"Luft","sequence":"first","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6389-1072","authenticated-orcid":false,"given":"Ramzi","family":"Khattar","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaveh","family":"Farrokhi","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Yavorska","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-9691","authenticated-orcid":false,"given":"Hassan","family":"Sadozai","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oyedele","family":"Adeyi","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Chruscinski","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Levy","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"},{"name":"Department of Immunology University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazia","family":"Selzner","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Multi Organ Transplant Programme Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.061"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60164-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3831"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00027-09"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009731107"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02474-07"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1679"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.9.1383"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4911-4927.2003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0800997"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.5.F19"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061462"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.3.1257"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1492"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488712799363262"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/806061"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02691.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100213108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20649"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20454"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.012"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302232"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.09.006"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0902454"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00027-3"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10257"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838197"},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1128\/iai.61.11.4925-4928.1993","article-title":"An Fc\u03b3RII\u2010, Fc\u03b3RIII\u2010specific monoclonal antibody (2.4G2) decreases acute Trypanosoma cruzi infection in mice","volume":"61","author":"Araujo\u2010Jorge T","year":"1993","journal-title":"Infect Immun"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0882-4010(02)90524-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032197"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22684"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072309"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.249"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(91)90018-U"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.57.357"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.10.5408"},{"key":"e_1_2_9_39_1","volume-title":"Current Protocols in Immunology","author":"Coligan JE","year":"1998"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2004.04.017"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7375"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2008.09.023"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22012"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.8.4036"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811139106"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132577"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67008"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130901"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000523"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838338"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.020"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12354"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i15.2673"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.01.005"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.01.009"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12189"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225417"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12108"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1670"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10004"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv137"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.12897","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.12897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:09:52Z","timestamp":1695492592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.12897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/imm.12897"],"URL":"https:\/\/doi.org\/10.1111\/imm.12897","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,20]]},"assertion":[{"value":"2017-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}