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Characterization of the array of receptors that govern <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell education and activation revealed an unexpected relationship with the major histocompatibility molecules that <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells originally became well known for ignoring. Proceeding true to form, <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells continue to up\u2010end archetypal understanding of their ever\u2010expanding capabilities. Discovery that the <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell repertoire is extremely diverse and can be reshaped by particular viruses into unique subsets of adaptive <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells challenges, or at least broadens, the definition of immunological memory. This review provides an overview of studies identifying adaptive <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells, addressing the origins of <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell memory and introducing the heretical concept of <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells with extensive antigenic specificity. Whether these newly apparent properties reflect adaptive utilization of known <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cell attributes and receptors or a specially creative allocation from an undefined receptor array remains to be fully determined.<\/jats:p>","DOI":"10.1111\/imm.12898","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T14:58:36Z","timestamp":1516633116000},"page":"38-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Origins of natural killer cell memory: special creation or adaptive evolution"],"prefix":"10.1111","volume":"154","author":[{"given":"Kayla A.","family":"Holder","sequence":"first","affiliation":[{"name":"Immunology and Infectious Diseases Programme Division of BioMedical Sciences Faculty of Medicine Memorial University of Newfoundland St John's NL 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