{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:30:38Z","timestamp":1778862638181,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT 2011\u20102014"],"award-info":[{"award-number":["UBACyT 2011\u20102014"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2011\u20102013"],"award-info":[{"award-number":["PIP 2011\u20102013"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2014\u20102016"],"award-info":[{"award-number":["PIP 2014\u20102016"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Ultraviolet radiation (\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    r) promotes several well\u2010known molecular changes, which may ultimately impact on health. Some of these effects are detrimental, like inflammation, carcinogenesis and immunosuppression. On the other hand,\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    r also promotes vitamin D synthesis and other beneficial effects. We recently demonstrated that exposure to very low doses of\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    r on four consecutive days [repetitive low\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    d (rl\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    d)] does not promote an inflammatory state, nor the recruitment of neutrophils or lymphocytes, as the exposure to a single high\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    dose (sh\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    d) does. Moreover, rl\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    d reinforce the epithelium by increasing antimicrobial peptides transcription and epidermal thickness. The aim of this study was to evaluate the adaptive immune response after sh\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    d and rl\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    d, determining T\u2010cell and B\u2010cell responses. Finally, we challenged animals exposed to both irradiation procedures with\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    to study the overall effects of both innate and adaptive immunity during a cutaneous infection. We observed, as expected, a marked suppression of T\u2010cell and B\u2010cell responses after exposure to an sh\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    d but a novel and significant increase in both specific responses after exposure to rl\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    d. However, the control of the cutaneous\n                    <jats:italic>S. aureus<\/jats:italic>\n                    infection was defective in this last group, suggesting that responses against pathogens cannot be ruled out from isolated stimuli.\n                  <\/jats:p>","DOI":"10.1111\/imm.12901","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T14:30:23Z","timestamp":1517236223000},"page":"510-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Daily very low\n                    <scp>UV<\/scp>\n                    dose exposure enhances adaptive immunity, compared with a single high\u2010dose exposure. Consequences for the control of a skin infection"],"prefix":"10.1111","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3294-085X","authenticated-orcid":false,"given":"Eliana M.","family":"Cela","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Inmunolog\u00eda Buenos Aires Argentina"},{"name":"CONICET \u2013 Universidad de Buenos Aires Instituto de Estudios de la Inmunidad Humoral (IDEHU) Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cintia Daniela","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires Facultad de Medicina Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda Buenos Aires Argentina"},{"name":"CONICET \u2013 Universidad de Buenos Aires Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPaM) Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Inmunolog\u00eda Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Ledo","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires Facultad de Medicina Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda Buenos Aires Argentina"},{"name":"CONICET \u2013 Universidad de Buenos Aires Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPaM) Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela Laura","family":"Paz","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires Facultad de Farmacia y Bioqu\u00edmica C\u00e1tedra de Inmunolog\u00eda Buenos Aires Argentina"},{"name":"CONICET \u2013 Universidad de Buenos Aires Instituto de Estudios de la Inmunidad Humoral (IDEHU) Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Leoni","sequence":"additional","affiliation":[{"name":"CONICET \u2013 Universidad de Buenos Aires Instituto de Estudios de la Inmunidad Humoral (IDEHU) Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa In\u00e9s","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires Facultad de Medicina Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda Buenos Aires Argentina"},{"name":"CONICET \u2013 Universidad de Buenos Aires Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPaM) Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Gonz\u00e1lez Maglio","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires 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