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Circular <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s regulate gene expression through acting as competitive endogenous <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (ceRNAs) and modulating gene transcription. Accumulating evidence supports the implication of circRNAs in a variety of human diseases, but studies of circRNA role in systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>) are lacking. The present study measured the circRNA expression profiles in T cells from patients with <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> and healthy controls with human circRNA microarray and identified 127 differentially expressed circRNAs in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients. Down\u2010regulation of hsa_circ_0045272 in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> T cells was verified with quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Jurkat cells with stable hsa_circ_0045272 knockdown were generated using specific lentiviral short hairpin <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> for functional studies. Flow cytometric analysis indicated that hsa_circ_0045272 knockdown significantly up\u2010regulated the early apoptosis of Jurkat cells. Meanwhile, ELISA showed that hsa_circ_0045272 knockdown significantly enhanced interleukin\u20102 production of activated Jurkat cells. Then, ceRNAs were predicted for hsa_circ_0045272 and the significant down\u2010regulation of two <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s predicted as ceRNAs, <jats:styled-content style=\"fixed-case\">NM<\/jats:styled-content>_003466 (<jats:styled-content style=\"fixed-case\">PAX<\/jats:styled-content>8) and <jats:styled-content style=\"fixed-case\">NM<\/jats:styled-content>_015177 (<jats:styled-content style=\"fixed-case\">DTX<\/jats:styled-content>4), but not their corresponding proteins, was validated. Furthermore, dual luciferase reporter assay indicated binding of hsa_circ_0045272 with hsa\u2010miR\u20106127. Circular <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> co\u2010expression networks showed the correlation of circRNAs with <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s and provided additional clues to circRNA functions. Our study demonstrated dysregulated circRNAs in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> and revealed the function of hsa_circ_0045272 in negatively regulating apoptosis and interleukin\u20102 secretion and its potential mechanism. The implication of hsa_circ_0045272 and other abnormal circRNAs in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> merits further investigation.<\/jats:p>","DOI":"10.1111\/imm.12940","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:38:32Z","timestamp":1524789512000},"page":"137-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Circular <scp>RNA<\/scp> expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus"],"prefix":"10.1111","volume":"155","author":[{"given":"Lian\u2010Ju","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei Anhui China"},{"name":"Anhui Province Key Laboratory of Major Autoimmune Diseases Hefei Anhui 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