{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:23:28Z","timestamp":1792157008179,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Summary<\/jats:title>Pemphigus foliaceus (PF<\/jats:styled-content>) is a blistering autoimmune skin disease rare in most of the world but endemic in certain regions of Brazil. PF<\/jats:styled-content> is characterized by the detachment of epidermal cells and the presence of autoantibodies against desmoglein 1. In previous studies, we have shown that genetic polymorphisms and variable expression levels of certain leucocyte receptor complex (LRC<\/jats:styled-content>) genes were associated with PF<\/jats:styled-content>. However, the role of the LRC<\/jats:styled-content> on PF<\/jats:styled-content> susceptibility remained to be investigated. Here, we analysed 527 tag single nucleotide polymorphisms (SNPs<\/jats:styled-content>) distributed within the 1\u00b75\u2005Mb LRC<\/jats:styled-content>. After quality control, a total of 176 SNP<\/jats:styled-content>s were analysed in 229 patients with PF<\/jats:styled-content> and 194 controls. Three SNP<\/jats:styled-content>s were associated with differential susceptibility to PF<\/jats:styled-content>. The intergenic variant rs465169<\/jats:italic> [odds ratio (OR)\u2005<\/jats:styled-content>=\u20051\u00b750; P\u2005<\/jats:italic>=\u20050\u00b7004] is located in a region that might regulate several immune\u2010related genes, including VSTM<\/jats:styled-content>1<\/jats:italic>, LILRB<\/jats:styled-content>1\/2<\/jats:italic>, LAIR<\/jats:styled-content>1\/2<\/jats:italic>, LILRA<\/jats:styled-content>3\/4<\/jats:italic> and LENG<\/jats:styled-content>8<\/jats:italic>. The rs35336528<\/jats:italic> (OR\u2005<\/jats:styled-content>=\u20053\u00b744; P\u2005<\/jats:italic>=\u20050\u00b7009) and rs1865097<\/jats:italic> (OR\u2005<\/jats:styled-content>=\u20050\u00b757; P\u2005<\/jats:italic>=\u20050\u00b7005) SNP<\/jats:styled-content>s in LENG<\/jats:styled-content>8<\/jats:italic> and FCAR<\/jats:styled-content><\/jats:italic> genes, respectively, were also associated with PF<\/jats:styled-content>. Moreover, we found four haplotypes with SNP<\/jats:styled-content>s within the KIR<\/jats:styled-content>3DL<\/jats:styled-content>2\/3<\/jats:italic>, LAIR<\/jats:styled-content>2<\/jats:italic> and LILRB<\/jats:styled-content>1<\/jats:italic> genes associated with PF<\/jats:styled-content> (P\u2005<\/jats:italic><\u20050\u00b705), which corroborate previously reported associations. Thus, our results confirm the importance of the LRC<\/jats:styled-content> for differential susceptibility to PF<\/jats:styled-content> and reveal new markers that might influence expression levels of several LRC<\/jats:styled-content> genes, as well as candidates for further functional studies.<\/jats:p>","DOI":"10.1111\/imm.13003","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T06:49:47Z","timestamp":1537080587000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation"],"prefix":"10.1111","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-2428","authenticated-orcid":false,"given":"Ticiana Della Justina","family":"Farias","sequence":"first","affiliation":[{"name":"Laboratory of Human Molecular Genetics Department of Genetics Federal University of Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danillo G.","family":"Augusto","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics Department of Genetics Federal University of Paran\u00e1 Curitiba Brazil"},{"name":"Biological Sciences Universidade Estadual de Santa Cruz Ilh\u00e9us Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Coutinho","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Molecular Epidemiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Malheiros","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics Department of Genetics Federal University of Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-5276","authenticated-orcid":false,"given":"Maria Luiza","family":"Petzl\u2010Erler","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics Department of Genetics Federal University of Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5252"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01743.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2004.00833.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02493.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220081019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12029"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.047"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.07.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12456932"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365845"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1989.tb01684.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363939"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.04.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.08.006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.36"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.04.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.06.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2016.07.006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2017.1329830"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00695"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900961"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00653.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002510000187"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039991"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-015-1626-6"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445324"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12315"},{"key":"e_1_2_10_29_1","first-page":"1448","volume-title":"Molecular 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