{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:16:15Z","timestamp":1762157775646,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["81373123","81611130078"],"award-info":[{"award-number":["81373123","81611130078"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Summary<\/jats:title>Nuclear receptor peroxisome proliferator\u2010activated receptor \u03b3<\/jats:italic> (PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic>) activation can prevent immunoinflammatory disorders and diabetes. B cells play protective roles during inflammation as well. However, the roles of endogenous PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic> in the regulatory properties of B cells to relieve inflammation remain unknown. Here, we developed B\u2010cell\u2010specific PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic> knockout (B\u2010PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic>\u2212\/\u2212<\/jats:sup>) mice and found that the conditional deletion of PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic> in B cells resulted in exaggerated contact hypersensitivity (CHS<\/jats:styled-content>). Meanwhile, interferon\u2010\u03b3<\/jats:italic> (IFN<\/jats:styled-content>\u2010\u03b3<\/jats:italic>) of CD<\/jats:styled-content>4+<\/jats:sup> CD<\/jats:styled-content>8+<\/jats:sup> T cells was up\u2010regulated in B\u2010PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic>\u2212\/\u2212<\/jats:sup> mice in CHS<\/jats:styled-content>. This showed that the regulatory function of B cells in B\u2010PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic>\u2212\/\u2212<\/jats:sup> mice declined in vivo<\/jats:italic>. Whereas splenic CD<\/jats:styled-content>5+<\/jats:sup> CD<\/jats:styled-content>1dhi<\/jats:sup> regulatory B\u2010cell numbers and peripheral regulatory T\u2010cell numbers were not changed in naive B\u2010PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic>\u2212\/\u2212<\/jats:sup> mice. Loss of PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic> in B cells also did not affect either CD<\/jats:styled-content>86 or FasL expression in splenic CD<\/jats:styled-content>5+<\/jats:sup> CD<\/jats:styled-content>1dhi<\/jats:sup> regulatory B cells after activation. Notably, interleukin\u201010 (IL<\/jats:styled-content>\u201010) production in CD<\/jats:styled-content>5+<\/jats:sup> CD<\/jats:styled-content>1dhi<\/jats:sup> regulatory B cells reduced in B\u2010PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic>\u2010deficient mice. In addition, functional IL<\/jats:styled-content>\u201010\u2010producing CD<\/jats:styled-content>5+<\/jats:sup> CD<\/jats:styled-content>1dhi<\/jats:sup> regulatory B cells decreased in B\u2010PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic>\u2212\/\u2212<\/jats:sup> mice in the CHS<\/jats:styled-content> model. These findings were in accordance with augmented CHS<\/jats:styled-content>. The current work indicated the involvement of endogenous PPAR<\/jats:styled-content>\u2010\u03b3<\/jats:italic> in the regulatory function of B cells by disturbing the expansion of IL<\/jats:styled-content>\u201010\u2010positive regulatory B cells.<\/jats:p>","DOI":"10.1111\/imm.13027","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T16:34:09Z","timestamp":1543077249000},"page":"282-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["B\u2010cell\u2010specific\u2010peroxisome proliferator\u2010activated receptor \u03b3<\/i> deficiency augments contact hypersensitivity with impaired regulatory B cells"],"prefix":"10.1111","volume":"156","author":[{"given":"Jianbing","family":"Su","sequence":"first","affiliation":[{"name":"Laboratory of Anti\u2010inflammatory and Immunomodulatory Pharmacology School of Pharmaceutical Sciences Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keng","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Anti\u2010inflammatory and Immunomodulatory Pharmacology School of Pharmaceutical Sciences Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhujiang Hospital Southern Medical University Guangzhou China"},{"name":"State Key Laboratory of Organ Failure Research Department of Cell Biology School of Basic Medical Sciences Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Anti\u2010inflammatory and Immunomodulatory Pharmacology School of Pharmaceutical Sciences Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialan","family":"Xu","sequence":"additional","affiliation":[{"name":"Laboratory of Anti\u2010inflammatory and Immunomodulatory Pharmacology School of Pharmaceutical Sciences Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 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