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Regulatory T\u2010cells (Tregs) are prevalent in nearly all cancers and, as immunosuppressive regulators of immune responses, they are the principal opponents of cancer immunotherapy. However, disabling Tregs systemically causes severe autoimmune toxicity, hastening the need for more selective methods to target intratumoural Tregs. In this review, we discuss a burgeoning new modality to specifically target tumour\u2010infiltrating Tregs (\n                    <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content>\n                    \u2010Tregs) by reprogramming their functionality from immunosuppressive to immune stimulatory within tumours. As the basis for therapeutic selectivity of\n                    <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content>\n                    \u2010Tregs, we will focus on the defining features of Tregs within cancer: their highly activated state controlled by the engagement of key surface receptors, their distinct metabolic programme, and their unique transcriptional programme. By identifying proteins and pathways that distinguish\n                    <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content>\n                    \u2010Tregs from other Tregs in the body, as well as from the beneficial antitumour effector T\u2010cells within tumours, we highlight mechanisms to selectively reprogramme\n                    <jats:styled-content style=\"fixed-case\">TI<\/jats:styled-content>\n                    \u2010Tregs for the treatment of cancer.\n                  <\/jats:p>","DOI":"10.1111\/imm.13058","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T17:36:30Z","timestamp":1552498590000},"page":"198-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Treg programming and therapeutic reprogramming in cancer"],"prefix":"10.1111","volume":"157","author":[{"given":"Mariela A.","family":"Moreno 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