{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:11:05Z","timestamp":1790802665086,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Current treatments for systemic autoimmune diseases partially improve the health of patients displaying low pharmacological efficacy and systemic immunosuppression. Here, the therapeutic potential of transferring tolerogenic dendritic cells (tolDCs) generated with heme\u2010oxygenase inductor cobalt (III) protoporphyrin IX (CoPP), dexamethasone and rosiglitazone for the treatment of systemic autoimmunity was evaluated in two murine models of systemic lupus erythematosus (SLE), MRL\u2010Fas<jats:sup>lpr<\/jats:sup> and NZM2410 mice. Dendritic cells treated <jats:italic>ex vivo<\/jats:italic> with these drugs showed a stable tolerogenic profile after lipopolysaccharide stimulation. Regular doses of tolDCs were administered to anti\u2010nuclear antibody\u2010positive mice throughout 60\u201370\u00a0days, and\u00a0the clinical score was evaluated. Long\u2010term treatment with these tolDCs was well tolerated and effective to improve the clinical score on MRL\u2010Fas<jats:sup>lpr<\/jats:sup> lupus\u2010prone mice. Additionally, decreased levels of anti\u2010nuclear antibodies in NZM2410 mice were observed. Although tolDC treatment increased regulatory T cells, no significant reduction of renal damage or glomerulonephritis could be found. In conclusion, these results suggest that the transfer of histone\u2010loaded tolDCs could improve only some SLE symptoms and reduced anti\u2010nuclear antibodies. This is the first study to evaluate antigen\u2010specific tolDC administration to treat SLE. Our report strengthens the clinical relevance of tolDC generation with CoPP, dexamethasone and rosiglitazone and the use of these modified cells as a therapy for systemic autoimmunity.<\/jats:p>","DOI":"10.1111\/imm.13119","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T15:24:46Z","timestamp":1568215486000},"page":"322-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice"],"prefix":"10.1111","volume":"158","author":[{"given":"Samanta C.","family":"Funes","sequence":"first","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago 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