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Dendritic cells (DCs) activate cytotoxic CD8<jats:sup>+<\/jats:sup> T\u2010cells and initiate immune responses against the parasites. <jats:italic>Batf3<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice lack a DC subset, which efficiently induces strong CD8 T\u2010cell responses by cross\u2010presentation of exogenous antigens. Here we show that <jats:italic>Batf3<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice infected with <jats:italic>Plasmodium berghei ANKA<\/jats:italic> (PbA) were protected from experimental CM (ECM), characterized by a stable blood\u2212brain barrier (BBB)\u00a0and significantly less infiltrated peripheral immune cells in the brain. Importantly, the absence of ECM in <jats:italic>Batf3<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice correlated with attenuated responses of cytotoxic T\u2010cells, as their parasite\u2010specific lytic activity as well as the production of interferon gamma and granzyme B were significantly decreased. Remarkably, spleens of ECM\u2010protected <jats:italic>Batf3<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice had elevated levels of regulatory immune cells and interleukin 10. Thus, protection from ECM in PbA\u2010infected <jats:italic>Batf3<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice was associated with the absence of strong CD8<jats:sup>+<\/jats:sup> T\u2010cell activity and induction of immunoregulatory mediators and cells.<\/jats:p>","DOI":"10.1111\/imm.13137","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T08:04:48Z","timestamp":1571645088000},"page":"193-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Protection of <i>Batf3<\/i>\u2010deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T\u2010cell responses and immune regulation"],"prefix":"10.1111","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3648-2649","authenticated-orcid":false,"given":"Janina M.","family":"Kuehlwein","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and 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