{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:04:51Z","timestamp":1787605491109,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL134544"],"award-info":[{"award-number":["HL134544"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Oxidized low\u2010density lipoprotein (LDL) contributes to cardiovascular disease in part by mediating activation and maturation of monocytes and macrophages. Furthermore, co\u2010localization studies using histochemical approaches have implicated a potential role for oxidized LDL as a mediator of interleukin\u201015 (IL\u201015) expression in myeloid cells of atherosclerotic plaque. The latter activity could be an important pro\u2010inflammatory mechanism that mediates myeloid cell\/T\u2010cell crosstalk. Here, we examined the responses of primary human monocytes to highly oxidized LDL molecules. Oxidized LDL readily induced secretion of chemokines MCP\u20101 (CCL2) and GRO\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (CXCL1) but unlike lipopolysaccharide (LPS), has limited capacity to induce a variety of other cytokines including tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20106, IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and interferon\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010induced protein\u201010 and also displayed a poor capacity to induce p\u2010Akt or P\u2010S6 signaling. Failure of oxidized LDL to induce IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    secretion was associated with limited induction of caspase\u20101 activation. Furthermore, despite finding evidence that oxidized LDL could enhance the expression of IL\u201015 and IL\u201015 receptor expression in monocytes, we found no evidence that it could confer IL\u201015 transpresentation capability to these cells. This observation contrasted with induction of IL\u201015 transpresentation in lipopolysaccharide\u2010stimulated monocytes. Overall, our data suggest that highly oxidized LDL is a selective inducer of monocyte activation. Sterile inflammatory mediators, particularly those implicated in Toll\u2010like receptor 4 signaling, may play a role in vascular pathology but the activities of these agents are not uniform.\n                  <\/jats:p>","DOI":"10.1111\/imm.13142","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T04:51:32Z","timestamp":1572411092000},"page":"221-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Highly oxidized low\u2010density lipoprotein mediates activation of monocytes but does not confer interleukin\u20101\n                    <i>\u03b2<\/i>\n                    secretion nor interleukin\u201015 transpresentation function"],"prefix":"10.1111","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-8682","authenticated-orcid":false,"given":"Scott F.","family":"Sieg","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine Department of Medicine Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Bazdar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine Department of Medicine Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zidar","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freeman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine Department of Medicine Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Lederman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine Department of Medicine Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas T.","family":"Funderburg","sequence":"additional","affiliation":[{"name":"Division of Medical Laboratory Science School of Health and Rehabilitation Sciences Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-011-6341-5"},{"key":"e_1_2_8_3_1","first-page":"38","article-title":"Oxidative modification of LDL in the pathogenesis of atherosclerosis","volume":"2","author":"Steinberg D","year":"1993","journal-title":"Am J Geriatr Cardiol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800087-JLR200"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.11.028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-029-8_24"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.08.038"},{"key":"e_1_2_8_8_1","first-page":"181","article-title":"The role of the monocyte in atherogenesis: I. 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