{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:44:54Z","timestamp":1790707494253,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Toll\u2010like receptor 10 (TLR10) is the only member of the human Toll\u2010like receptor family with an inhibitory function on the induction of innate immune responses and inflammation. However, its role in the modulation of trained immunity (innate immune memory) is unknown. In the present study, we assessed whether TLR10 modulates the induction of trained immunity induced by <jats:italic>\u03b2<\/jats:italic>\u2010glucan or bacillus Calmette\u2013Gu\u00e9rin (BCG). Interleukin 10 receptor antagonist production was increased upon activation of TLR10 <jats:italic>ex vivo<\/jats:italic> after BCG vaccination, and TLR10 protein expression on monocytes was increased after BCG vaccination, whereas anti\u2010TLR10 antibodies did not significantly modulate <jats:italic>\u03b2<\/jats:italic>\u2010glucan or BCG\u2010induced trained immunity <jats:italic>in vitro<\/jats:italic>. A known immunomodulatory TLR10 missense single\u2010nucleotide polymorphism (rs11096957) influenced trained immunity responses by <jats:italic>\u03b2<\/jats:italic>\u2010glucan or BCG <jats:italic>in vitro<\/jats:italic>. However, the <jats:italic>in vivo<\/jats:italic> induction of trained immunity by BCG vaccination was not influenced by TLR10 polymorphisms. In conclusion, TLR10 has a limited, non\u2010essential impact on the induction of trained immunity in humans.<\/jats:p>","DOI":"10.1111\/imm.13145","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T19:19:33Z","timestamp":1572549573000},"page":"289-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The role of Toll\u2010like receptor 10 in modulation of trained immunity"],"prefix":"10.1111","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-5145","authenticated-orcid":false,"given":"Vera P.","family":"Mourits","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Radboud Center for Infectious Diseases (RCI) Radboud Institute of Molecular Life Sciences (RIMLS) Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J.W.","family":"Arts","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud Center for Infectious Diseases (RCI) Radboud Institute of Molecular Life Sciences (RIMLS) Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Novakovic","sequence":"additional","affiliation":[{"name":"Epigenetics Research Murdoch Children's Research Institute Parkville Vic. 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Charlotte J.","family":"de Bree","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud Center for Infectious Diseases (RCI) Radboud Institute of Molecular Life Sciences (RIMLS) Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Research Center for Vitamins and Vaccines Bandim Health Project Statens Serum Institut Copenhagen Denmark"},{"name":"Odense Patient Data Explorative Network University of Southern Denmark\/Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.C.M.","family":"Koeken","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud Center for Infectious Diseases (RCI) Radboud Institute of Molecular Life Sciences (RIMLS) Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone 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