{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:04:14Z","timestamp":1792202654510,"version":"4.4.0"},"reference-count":136,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Helminth parasites infect an alarmingly large proportion of the world's population, primarily within tropical regions, and their ability to down\u2010modulate host immunity is key to their persistence. Helminths have developed multiple mechanisms that induce a state of hyporesponsiveness or immune suppression within the host; of particular interest are mechanisms that drive the induction of regulatory T\u2010cells (Tregs). Helminths actively induce Tregs either directly by secreting factors, such as the TGF\u2010\u03b2 mimic\n                    <jats:italic>Hp\u2010<\/jats:italic>\n                    TGM, or indirectly by interacting with bystander cell types such as dendritic cells and macrophages that then induce Tregs. Expansion of Tregs not only enhances parasite survival but, in cases such as filarial infection, Tregs also play a role in preventing parasite\u2010associated pathologies. Furthermore, Tregs generated during helminth infection have been associated with suppression of bystander immunopathologies in a range of inflammatory conditions such as allergy and autoimmune disease. In this review, we discuss evidence from natural and experimental infections that point to the pathways and molecules involved in helminth Treg induction, and postulate how parasite\u2010derived molecules and\/or Tregs might be applied as anti\u2010inflammatory therapies in the future.\n                  <\/jats:p>","DOI":"10.1111\/imm.13190","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T03:05:30Z","timestamp":1583809530000},"page":"248-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Regulatory T\u2010cells in helminth infection: induction, function and therapeutic potential"],"prefix":"10.1111","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0152-1110","authenticated-orcid":false,"given":"Madeleine P. 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