{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:46:28Z","timestamp":1787859988452,"version":"build-2784847793"},"reference-count":167,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18PRE34030086"],"award-info":[{"award-number":["18PRE34030086"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Macrophages are fundamental to sustain physiological equilibrium and to regulate the pathogenesis of parasitic and metabolic processes. The functional heterogeneity and immune responses of macrophages are shaped by cellular metabolism in response to the host\u2019s intrinsic factors, environmental cues and other stimuli during disease. Parasite infections induce a complex cascade of cytokines and metabolites that profoundly remodel the metabolic status of macrophages. In particular, helminths polarize macrophages to an M2 state and induce a metabolic shift towards reliance on oxidative phosphorylation, lipid oxidation and amino acid metabolism. Accumulating data indicate that helminth\u2010induced activation and metabolic reprogramming of macrophages underlie improvement in overall whole\u2010body metabolism, denoted by improved insulin sensitivity, body mass in response to high\u2010fat diet and atherogenic index in mammals. This review aims to highlight the metabolic changes that occur in human and murine\u2010derived macrophages in response to helminth infections and helminth products, with particular interest in schistosomiasis and soil\u2010transmitted helminths.<\/jats:p>","DOI":"10.1111\/imm.13231","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T20:43:22Z","timestamp":1593722602000},"page":"123-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Schistosome and intestinal helminth modulation of macrophage immunometabolism"],"prefix":"10.1111","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9203-2090","authenticated-orcid":false,"given":"Diana","family":"Cortes\u2010Selva","sequence":"first","affiliation":[{"name":"Division of Microbiology and Immunology Department of Pathology University of Utah Salt Lake City UT USA"},{"name":"Janssen Biotherapeutics Janssen R&amp;D Spring House PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8382-2960","authenticated-orcid":false,"given":"Keke","family":"Fairfax","sequence":"additional","affiliation":[{"name":"Division of Microbiology and Immunology Department of Pathology University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.34"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.12.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61022-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-403"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61356-w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.7.2527.2527"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053119"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200101)31:1<48::AID-IMMU48>3.0.CO;2-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-326827"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01726"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2006.05.025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02035"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144351"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-258558"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00174-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032152"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11852"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3343"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10321"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2967"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080421"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1246"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0403164"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004282"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004080"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847796"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.016"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13989"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.011"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.016"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2419"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03133"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800544115"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0872"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131199"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0361OC"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0352-y"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101198"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00544.2014"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132964"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.024"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12192"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3320"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02019"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80541-3"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300581"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00837"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4238"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300342"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.11.004"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.11"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.07.004"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2008.02.013"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040137"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1157643"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2398"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.048"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88879"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/816460"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061801"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.005"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145342"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12384-2"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0012OC"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.05.011"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071545"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02251-w"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.012"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RU1018-378RR"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007000"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002490"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.02.016"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-072587"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194126"},{"key":"e_1_2_9_81_1","article-title":"Metabolic immunomodulation, transcriptional regulation, and signal protein expression define the metabotype and effector functions of five polarized macrophage phenotypes","author":"Anders CB","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-2656-4"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00664"},{"key":"e_1_2_9_84_1","volume-title":"Medical Microbiology","author":"Castro GA","year":"1996"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-37"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34261"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000114"},{"key":"e_1_2_9_88_1","first-page":"467","volume-title":"Disease Control Priorities in Developing Countries","author":"Hotez PJ","year":"2006"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30346-8"},{"issue":"1","key":"e_1_2_9_90_1","first-page":"3","article-title":"Mortality and disability\u2010adjusted life\u2010years (DALYs) for common neglected tropical diseases in Ethiopia, 1990\u20132015: evidence from the Global Burden of Disease Study 2015","volume":"55","author":"Deribew A","year":"2017","journal-title":"Ethiop Med J"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000227"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.123"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.09.015"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.04.005"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500093R"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2790627"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.07.002"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-520619"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.30947"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601975"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/743758"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03134.x"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20633"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000707"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127746"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2517"},{"key":"e_1_2_9_107_1","article-title":"The effect of helminth infections and their treatment on metabolic outcomes: results of a cluster\u2010randomised trial","author":"Sanya RE","year":"2019","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086017"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.05.011"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00453"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045974"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/262609"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-3871-y"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61949-2"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00107-4"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301357"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178636119849934"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0306-7"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2400-5"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-266239"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141869"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3621-6"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.312355.118"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05894"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/22572"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.11.006"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7348372"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.08.003"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007924"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01160-5"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.11.002"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006364"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500146"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03137"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02580"},{"key":"e_1_2_9_136_1","first-page":"050898","article-title":"Schistosoma mansoni infection reprograms the metabolic potential of the myeloid lineage in a mouse model of metabolic syndrome","author":"Cortes\u2010Selva D","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3796"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2017.04.001"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3260-6"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60040-4"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.2307\/3546767"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082460"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082462"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-277822"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2956"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.016"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00362.2014"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2018.02.028"},{"key":"e_1_2_9_149_1","doi-asserted-by":"crossref","first-page":"e0136002","DOI":"10.1371\/journal.pone.0136002","article-title":"Correction: infection with soil\u2010transmitted helminths is associated with increased insulin sensitivity","volume":"10","author":"Wiria AE","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0546-0"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201475"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202502"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004140"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.04.008"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182016000020"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.014"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy935"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.7.4721"},{"key":"e_1_2_9_159_1","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.MCHD-0043-2016","article-title":"Myeloid cell phenotypes in susceptibility and resistance to helminth parasite infections","volume":"4","author":"Maizels RM","year":"2016","journal-title":"Microbiol Spectr"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059441"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34174-4"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22920-7"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121964"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00053-13"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0112"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125945"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1908-4"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21299"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.13231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.13231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T12:17:07Z","timestamp":1693743427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.13231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":167,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/imm.13231"],"URL":"https:\/\/doi.org\/10.1111\/imm.13231","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,27]]},"assertion":[{"value":"2020-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}