{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:25:52Z","timestamp":1790515552120,"version":"4.1.0"},"reference-count":189,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_12010\/10"],"award-info":[{"award-number":["MC_UU_12010\/10"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Iron is an essential element for almost all living organisms, but can be extremely toxic in high concentrations. All organisms must therefore employ homeostatic mechanisms to finely regulate iron uptake, usage and storage in the face of dynamic environmental conditions. The critical step in mammalian systemic iron homeostasis is the fine regulation of dietary iron absorption. However, as the gastrointestinal system is also home to &gt;10<jats:sup>14<\/jats:sup> bacteria, all of which engage in their own programmes of iron homeostasis, the gut represents an anatomical location where the inter\u2010kingdom fight for iron is never\u2010ending. Here, we explore the molecular mechanisms of, and interactions between, host and bacterial iron homeostasis in the gastrointestinal tract. We first detail how mammalian systemic and cellular iron homeostasis influences gastrointestinal iron availability. We then focus on two important human pathogens, <jats:italic>Salmonella<\/jats:italic> and <jats:italic>Clostridia<\/jats:italic>; despite their differences, they exemplify how a bacterial pathogen must navigate and exploit this web of iron homeostasis interactions to avoid host nutritional immunity and replicate successfully. We then reciprocally explore how iron availability interacts with the gastrointestinal microbiota, and the consequences of this on mammalian physiology and pathogen iron acquisition. Finally, we address how understanding the battle for iron in the gastrointestinal tract might inform clinical practice and inspire new treatments for important diseases.<\/jats:p>","DOI":"10.1111\/imm.13236","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T09:19:15Z","timestamp":1594199955000},"page":"186-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The battle for iron in enteric infections"],"prefix":"10.1111","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-755X","authenticated-orcid":false,"given":"Ana","family":"Sousa Ger\u00f3s","sequence":"first","affiliation":[{"name":"MRC Human Immunology Unit Weatherall Institute of Molecular Medicine University of Oxford Oxford UK"},{"name":"Translational Gastroenterology Unit John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Simmons","sequence":"additional","affiliation":[{"name":"MRC Human Immunology Unit Weatherall Institute of Molecular Medicine University of Oxford Oxford UK"},{"name":"Translational Gastroenterology Unit John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-6103","authenticated-orcid":false,"given":"Hal","family":"Drakesmith","sequence":"additional","affiliation":[{"name":"MRC Human Immunology Unit Weatherall Institute of Molecular Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-2796","authenticated-orcid":false,"given":"Anna","family":"Aulicino","sequence":"additional","affiliation":[{"name":"MRC Human Immunology Unit Weatherall Institute of Molecular Medicine University of Oxford Oxford UK"},{"name":"Translational Gastroenterology Unit John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe N.","family":"Frost","sequence":"additional","affiliation":[{"name":"MRC Human Immunology Unit Weatherall Institute of Molecular Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1930"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400415k"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i35.4716"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1151-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1843"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219664"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(83)91040-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio0308-152"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.09.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510011489"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"1461S","DOI":"10.3945\/ajcn.2010.28674F","article-title":"Iron bioavailability and dietary reference values","volume":"91","author":"Hurrell R","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-383"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24356"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1057206"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0716"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5686.778"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.12.5.369"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00167.2016"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.005"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105749"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000713200"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35001596"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.01.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80425-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098792"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/5979"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04446-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/7727"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-003681"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.034"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0330-6"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.08.015"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2006_3296"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150787"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10308"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00238"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.061505.111303"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008923200"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.151179498"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1053"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1766"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-258467"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3863"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-786590"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.03.018"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-380337"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.12.012"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.03.007"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI122359"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00176"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.02.026"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.08.003"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1353\/pbm.1997.0072"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5471.1651"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.20.6223-6229.1999"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(00)00184-3"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00116-09"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.01.029"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/28893"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.21.5826-5832.2002"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00055-X"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00059"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.98"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2019.504-521"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091313-103739"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00428"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090110-102824"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1085"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.16.4973-4982.2003"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3mt20224k"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2016.04.004"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-11-236"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.1155-1158.2004"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05600.x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.6.1835-1842.2001"},{"key":"e_1_2_9_77_1","first-page":"33","article-title":"Control by Fur of the nitrate respiration regulators NarP and NarL in Salmonella enterica","volume":"13","author":"Teixid\u00f3 L","year":"2010","journal-title":"Int Microbiol"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.19.5683-5691.1996"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019711"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00926-07"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00942-10"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029968"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05701.x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.064329-0"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00693-08"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2010.01967.x"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.03.018"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.14.3774-3784.2002"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.9.2907-2914.1997"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(91)90033-7"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00098-15"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03183"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/fty009"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.184.4140.952"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545569"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.06.017"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224577"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008922200"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16670"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-772715"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00253-18"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.12.001"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-218185"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00152"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3483"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-550467"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6481"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808426115"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126645"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.643973"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015831"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0425"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.9.1237"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax7898"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401551"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuv049"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12739"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.11.4549-4556.1996"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00043-3"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1891"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BIOM.0000027696.48707.42"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1259329"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0284-4"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8113"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03104"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00710-4"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.01.003"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064559"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0737682100"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604636103"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.08.001"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.03.011"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.4.1610-1618.1999"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2012.04.007"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02289-19"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51628-5"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00081"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00055"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.2.489"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2008.02.006"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai8371"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20120066"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00048-16"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.05.015"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007486"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1453-3"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0256-8"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18849"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18848"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600266"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60437-7"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7373.1142"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307720"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.004564"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.156067"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070776"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013651"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.5.3065-3067.2006"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8451"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545642"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01481"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2012.01461.x"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.01.010"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-276840"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.10.005"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400278"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2006.06.003"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.06.007"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20557"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01480"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.1.14-56.2004"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.7.3458"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606290113"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja503911p"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72336"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.145060"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy327"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122938"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3914"},{"key":"e_1_2_9_182_1","first-page":"104","article-title":"Management of iron deficiency anemia in inflammatory bowel disease \u2013 a practical approach","volume":"26","author":"Stein J","year":"2013","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k3165"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117383"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.12688\/gatesopenres.12866.1"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.220830"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-642223"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01540"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507645112"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01809"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimm.13236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.13236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T21:31:44Z","timestamp":1693863104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.13236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":189,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/imm.13236"],"URL":"https:\/\/doi.org\/10.1111\/imm.13236","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"assertion":[{"value":"2020-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}