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T<jats:sub>FH<\/jats:sub> cells express the transcription factor B\u2010cell lymphoma 6 (Bcl\u20106), chemokine (C\u2010X\u2010C motif) receptor (CXCR) 5, the surface receptors programmed cell death protein 1 (PD\u20101) and inducible T\u2010cell costimulator (ICOS), the cytokine IL\u201021 and other molecules. The activation, proliferation and differentiation of T<jats:sub>FH<\/jats:sub> cells are closely related to dynamic changes in cellular metabolism. In this review, we summarize the progress made in understanding the development and functional differentiation of T<jats:sub>FH<\/jats:sub> cells. Specifically, we focus on the regulatory mechanisms of T<jats:sub>FH<\/jats:sub> cell functional differentiation, including regulatory signalling pathways and the metabolic regulatory mechanisms of T<jats:sub>FH<\/jats:sub> cells. 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