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The theoretical diversity of the T\u2010cell receptor (TCR) repertoire exceeds the actual size of the T\u2010cell population in an individual by several orders of magnitude \u2013 making the observation of identical TCRs in different individuals extremely improbable if all receptors were equally likely. Despite this disparity between the theoretical and the realized diversity of the repertoire, these \u2018public\u2019 receptor sequences have been identified in autoimmune, cancer and pathogen interaction contexts. Biased generation processes explain the presence of public TCRs in the naive repertoire, but do not adequately explain the different abundances of these public TCRs. We investigate and characterize the distribution of genomic TCR\u2010\u03b2 sequences of naive CD8+ T cells from three genetically identical mice, comparing non\u2010productive (non\u2010functional sequences) and productive sequences. We find public TCR\u2010\u03b2 sequences at higher abundances compared with unshared sequences in the productive, but not in the non\u2010productive, repertoire. We show that neutral processes such as recombination biases, codon degeneracy and generation probability do not fully account for these differences, and conclude that thymic or peripheral selection plays an important role in increasing the abundances of public TCR\u2010\u03b2 sequences.<\/jats:p>","DOI":"10.1111\/imm.13299","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T12:28:32Z","timestamp":1608553712000},"page":"464-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Selection influences naive CD8+ TCR\u2010\u03b2 repertoire sharing"],"prefix":"10.1111","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1221-5722","authenticated-orcid":false,"given":"Hao H.","family":"Yiu","sequence":"first","affiliation":[{"name":"Department of Biology University of Maryland College Park MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis N.","family":"Schoettle","sequence":"additional","affiliation":[{"name":"School of Life Sciences The Biodesign Institute Arizona State University Tempe AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene","family":"Garcia\u2010Neuer","sequence":"additional","affiliation":[{"name":"School of Life Sciences The Biodesign Institute Arizona State University Tempe AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph N.","family":"Blattman","sequence":"additional","affiliation":[{"name":"School of Life Sciences The Biodesign Institute Arizona State University Tempe AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6087-7064","authenticated-orcid":false,"given":"Philip L. 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