{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T06:10:52Z","timestamp":1794118252828,"version":"4.8.0"},"reference-count":101,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Communication between stromal and immune cells is essential to maintain tissue homeostasis, mount an effective immune response and promote tissue repair. This \u2018crosstalk\u2019 occurs in both the steady state and following a variety of insults, for example, in response to local injury, at sites of infection or cancer. What do we mean by crosstalk between cells? Reciprocal activation and\/or regulation occurs between immune and stromal cells, by direct cell contact and indirect mechanisms, including the release of soluble cytokines. Moving beyond cell\u2010to\u2010cell contact, this review investigates the complexity of \u2018cross\u2010space\u2019 cellular communication. We highlight different examples of cellular communication by a variety of lung stromal and immune cells following tissue insults. This review examines how the \u2018geography of the lung microenvironment\u2019 is altered in various disease states; more specifically, we investigate how this influences lung epithelial cells and fibroblasts <jats:italic>via<\/jats:italic> their communication with immune cells and each other.<\/jats:p>","DOI":"10.1111\/imm.13319","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T18:35:25Z","timestamp":1612809325000},"page":"239-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Stromal\u2013immune cell crosstalk fundamentally alters the lung microenvironment following tissue insult"],"prefix":"10.1111","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7754-1364","authenticated-orcid":false,"given":"Julie C.","family":"Worrell","sequence":"first","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1843-8580","authenticated-orcid":false,"given":"Megan K. L.","family":"MacLeod","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402520"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.040"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu062"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-012-1335-0"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0238-1"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201909-1726LE"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17358-3"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0542-8"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.10.004"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2877-5"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070112"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.037267"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90067-6"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201439246"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.5.1747"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2787530"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1637"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1995.268.5.L856"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0292-x"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.11.014"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(02)00319-1"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.034"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53072"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1263-7"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2424-4"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0468-5"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03347-0"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.040"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201911-2199OC"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.009"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw3851"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465810396539"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028241"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117988108"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68782"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.03.009"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1837OC"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2297OC"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40139-017-0134-x"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.010"},{"key":"e_1_2_15_42_1","first-page":"L283","article-title":"Differential collagen and fibronectin production by Thy 1+ and Thy 1\u2010 lung fibroblast subpopulations","volume":"263","author":"Derdak S","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.03.020"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/01902140600880257"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162488599"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.09.007"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3713"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11714"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20192276"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61051-9"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.04.063"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3043"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12777"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.09.006"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.001"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.01.021"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14112"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3580"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.117"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800671"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1091"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.06.020"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1983"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1972"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.02.013"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01805-2016"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004903"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1671-8"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2011.10.004"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00353.2017"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019104063"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abc4557"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2106PP"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3767"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.8.5333"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-753OC"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5013"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737855"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028109"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6786-5_13"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091472"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.67"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00045"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111449"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13814"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131737"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181216"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140488"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008077"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00032.2019"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-107"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.12.012"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25786"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705751"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110551"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2410OC"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.015"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00646-2019"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02415.x"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0602-4"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6261"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.13319","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:23:48Z","timestamp":1693297428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.13319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":101,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/imm.13319"],"URL":"https:\/\/doi.org\/10.1111\/imm.13319","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,11]]},"assertion":[{"value":"2020-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}