{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:25:23Z","timestamp":1791998723957,"version":"4.4.0"},"reference-count":159,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1190830"],"award-info":[{"award-number":["1190830"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1190864"],"award-info":[{"award-number":["1190864"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Orthohantaviruses, previously named hantaviruses, cause two emerging zoonotic diseases: haemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Overall, over 200\u00a0000 cases are registered every year worldwide, with a fatality rate ranging between 0\u00b71% and 15% for HFRS and between 20% and 40% for HCPS. No specific treatment or vaccines have been approved by the U.S. Food and Drug Administration (FDA) to treat or prevent hantavirus\u2010caused syndromes. Currently, little is known about the mechanisms at the basis of hantavirus\u2010induced disease. However, it has been hypothesized that an excessive inflammatory response plays an essential role in the course of the disease. Furthermore, the contributions of the cellular immune response to either viral clearance or pathology have not been fully elucidated. This article discusses recent findings relative to the immune responses elicited to hantaviruses in subjects suffering HFRS or HCPS, highlighting the similarities and differences between these two clinical diseases. Also, we summarize the most recent data about the cellular immune response that could be important for designing new vaccines to prevent this global public health problem.<\/jats:p>","DOI":"10.1111\/imm.13322","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:33:55Z","timestamp":1614386035000},"page":"262-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Immune response during hantavirus diseases: implications for immunotherapies and vaccine design"],"prefix":"10.1111","volume":"163","author":[{"given":"Farides","family":"Saavedra","sequence":"first","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabi\u00e1n E.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angello","family":"Retamal\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Covi\u00e1n","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-5263","authenticated-orcid":false,"given":"Alexis M.","family":"Kalergis","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"},{"name":"Millennium Institute on Immunology and Immunotherapy Departamento de Endocrinolog\u00eda Facultad de Medicina Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"The ICTV Bunyaviridae Study Group.Create a new order Bunyavirales to accommodate nine families (eight new one renamed) comprising thirteen genera.2016;1\u201345."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00727"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01323234"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11090862"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6031317"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05452.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0706.2003.12226.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006901"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-09"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.7.6.15197"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0302.970210"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8976"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1112.050501"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-010-0814-x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11090788"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir232"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3066"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12291"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25446"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.6.1119"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.09.007"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2017.1293841"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/425007"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40506-020-00236-3"},{"issue":"1","key":"e_1_2_12_26_1","first-page":"410","article-title":"Humoral immune responses in the hantavirus cardiopulmonary syndrome","volume":"12","author":"Bharadwaj M","year":"2000","journal-title":"J Infect Dis."},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3297"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21302"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/314597"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.1.444-449.2002"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.06.006"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8827"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00399"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00482-20"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11090849"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11070610"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02989"},{"issue":"5","key":"e_1_2_12_38_1","first-page":"733","article-title":"Exposure characteristics of hantavirus pulmonary syndrome","volume":"23","author":"Maurice ADS","year":"2017","journal-title":"Emerg Infect Dis."},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/467059"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1208.051127"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235615"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.09.017"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-10182000000300008"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-73482002000100005"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-010-9245-4"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860229709026255"},{"key":"e_1_2_12_47_1","first-page":"1","article-title":"Hemorrhagic fever with renal syndrome: pathogenesis and clinical picture","volume":"6","author":"Jiang H","year":"2016","journal-title":"Front Cell Infect Microbiol."},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006462"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089740"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.01.003"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1086\/315153"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12259"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24260"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/674360"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0090-5"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/v5123109"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00576-10"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.1.444-449.2002"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-142"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001204000227"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00432"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24752"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00567"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2012.10.002"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005757"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz005"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.10.003"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328346a420"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.5.3951-3959.1999"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802893"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008483"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00454-20"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01168-19"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02347-14"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01088-13"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02647-13"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02402-06"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01586"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003272"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.066"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01072"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00281"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365549309008554"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100762"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004521"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401998111"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37446-1"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.21.10724-10733.2002"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243066"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3254"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-223"},{"key":"e_1_2_12_92_1","first-page":"1","article-title":"Immunocytochemical and ultrastructural evidence supporting that andes hantavirus (ANDV) is transmitted person\u2010to\u2010person through the respiratory and\/or salivary","volume":"10","author":"Pizarro E","year":"2020","journal-title":"Pathways."},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.08.003"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011255"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2592-1"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05548-11"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.11.007"},{"issue":"3","key":"e_1_2_12_98_1","first-page":"552","article-title":"Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease","volume":"146","author":"Zaki SR","year":"1995","journal-title":"Am J Pathol."},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000779"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05356-11"},{"key":"e_1_2_12_101_1","first-page":"1","article-title":"Comparison of lymphocyte populations in patients with Dobrava or Puumala orthohantavirus infection","volume":"10","author":"Rus KR","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707453104"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707454104"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00004-14"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002426"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-015-0085-0"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00430"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.35.12.3264-3268.1997"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(97)00053-1"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20759"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2079"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01319001"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(92)90132-W"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1201.050930"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890430108"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0602.000213"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12713"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131092"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu488"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.01.089"},{"key":"e_1_2_12_121_1","unstructured":"Ministerio de Salud.Direcci\u00f3n de Prevenci\u00f3n de Enfermedades (DIPRECE). Departamento de Enfermedades Transmisibles. Administraci\u00f3n de plasma hiperinmune para Hantavirus.2018.https:\/\/diprece.minsal.cl\/administracion\u2010de\u2010plasma\u2010inmune\u2010para\u2010hantavirus\/. Accessed October 10 2020."},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2875"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat6420"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00028-20"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010082"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00832"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-020-00146-3"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0634-9"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2013.783555"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/793257"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00057-2"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1608.090470"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy037"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.18.0044"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.02.022"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093454"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00373-09"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6020516"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11070645"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11329"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000897"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.18.8469-8477.2001"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.11.035"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.18.9894-9905.2003"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00546-12"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.12.011"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.13.6669-6677.2002"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.64.7.3162-3170.1990"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1089\/088282404322875511"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.03.045"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0702-1"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00794-11"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00333"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9586"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.07.025"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007278"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41205-1"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.01.031"},{"key":"e_1_2_12_159_1","unstructured":"WHO.Hantavirus pulmonary syndrome. Emergence preparedness response. Hantavirus pulmonary syndrome \u2010 Argentine Republic.2019."},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines6040084"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.13322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T04:24:06Z","timestamp":1693283046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.13322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":159,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/imm.13322"],"URL":"https:\/\/doi.org\/10.1111\/imm.13322","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]},"assertion":[{"value":"2020-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}