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Uropathogenic\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>\u00a0coli<\/jats:italic>\n                    (UPEC) are responsible for approximately 80% of all UTI, which most commonly affect the bladder. UPEC colonize the urinary tract by ascension of the urethra, followed by cell invasion, and proliferation inside and outside urothelial cells, thereby causing symptomatic infections and quiescent intracellular reservoirs that may lead to recurrence. Sugars, or glycans, are key molecules for host\u2013pathogen interactions, and UTI are no exception. Surface glycans regulate many of the events associated with UPEC adhesion and infection, as well as induction of the host immune response. While the bacterial protein FimH binds mannose\u2010containing host glycoproteins to initiate infection and UPEC\u2010secreted polysaccharides block immune mechanisms to favour intracellular replication, host glycans on the urothelial surface and on secreted glycoproteins prevent or limit infection by inhibiting UPEC adhesion. Given the importance of glycans during UTI, here we review the glycobiology of UPEC infection to highlight fundamental sugar\u2010mediated processes of immunological interest for their potential clinical applications. Interdisciplinary approaches incorporating glycomics and infection biology may help to develop novel non\u2010antibiotic\u2010based therapeutic strategies for bacterial infections as the spread of antimicrobial\u2010resistant uropathogens is currently threatening modern healthcare systems.\n                  <\/jats:p>","DOI":"10.1111\/imm.13330","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T21:45:40Z","timestamp":1616622340000},"page":"3-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The glycobiology of uropathogenic\n                    <i>E. coli<\/i>\n                    infection: the sweet and bitter role of sugars in urinary tract immunity"],"prefix":"10.1111","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-3137","authenticated-orcid":false,"given":"Federico","family":"Lupo","sequence":"first","affiliation":[{"name":"Institute of 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