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Monocytes\/macrophages (osteoclast precursors) have been recently recognized as important participants in the osteoclastogenesis of rheumatoid arthritis (RA) patients. Here, we aimed to investigate the therapeutic potential of IL\u20107\/IL\u20107R pathway in RA and to determine whether it could restrain osteoclastogenic functions and therefore ameliorate RA. Firstly, collagen\u2010induced arthritis (CIA) mice were administered with IL\u20107R\u03b1\u2010target antibodies to assess their therapeutic effect on arthritis. We found that blockade of the IL\u20107\/IL\u20107R pathway protected CIA mice from bone destruction in addition to inducing inflammatory remission, by altering the RANKL\/RANK\/OPG ratio and consequently decreasing osteoclast formation. To explore the effect and mechanism of this pathway, bone marrow cells were induced to osteoclasts and treated with IL\u20107, a STAT5 inhibitor or supernatants from T cells. The results showed that the IL\u20107\/IL\u20107R pathway played a direct inhibitory role in osteoclast differentiation via STAT5 signalling pathway in a RANKL\u2010induced manner. We applied flow cytometry to analyse the effect of IL\u20107 on T\u2010cell RANKL expression and found that IL\u20107\/IL\u20107R pathway had an indirect role in the osteoclast differentiation process by enhancing the RANKL expression on T cells. In conclusion, the IL\u20107\/IL\u20107R pathway exhibited a dual effect on osteoclastogenesis of CIA mice by interacting with osteoimmunology processes and could be a novel therapeutic target for autoimmune diseases such as RA.<\/jats:p>","DOI":"10.1111\/imm.13351","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T06:15:45Z","timestamp":1619936145000},"page":"161-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dual effect of IL\u20107\/IL\u20107R signalling on the osteoimmunological system: a potential therapeutic target for rheumatoid arthritis"],"prefix":"10.1111","volume":"164","author":[{"given":"Haiyan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology Shanghai Institute of Immunology Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"State Key Laboratory of Oncogenes and Related Genes Shanghai 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