{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:46:44Z","timestamp":1772160404851,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["207503\/Z\/17\/Z"],"award-info":[{"award-number":["207503\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["209213\/Z\/17\/Z"],"award-info":[{"award-number":["209213\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cytomegalovirus (CMV) induction of large frequencies of highly functional memory T cells has attracted much interest in the utility of CMV\u2010based vaccine vectors, with exciting preclinical data obtained in models of infectious diseases and cancer. However, pathogenesis of human CMV (HCMV) remains a concern. Attenuated CMV\u2010based vectors, such as replication\u2010 or spread\u2010deficient viruses, potentially offer an alternative to fully replicating vectors. However, it is not well understood how CMV attenuation impacts vector immunogenicity, particularly when administered via relevant routes of immunization such as the skin. Herein, we used the murine cytomegalovirus (MCMV) model to investigate the impact of vector attenuation on T\u2010cell memory formation following subcutaneous administration. We found that the spread\u2010deficient virus (\u0394gL\u2010MCMV) was impaired in its ability to induce memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells reactive to some (M38, IE1) but not all (IE3) viral antigens. Impaired\u2010memory T\u2010cell development was associated with a preferential and pronounced loss of polyfunctional (IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    TNF\u2010\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    ) T cells and also reduced accumulation of TCF1\n                    <jats:sup>+<\/jats:sup>\n                    T cells, and was not rescued by increasing the dose of replication\u2010defective MCMV. Finally, whilst vector attenuation reduced dendritic cell (DC) recruitment to skin\u2010draining lymph nodes, systematic depletion of multiple DC subsets during acute subcutaneous MCMV infection had a negligible impact on T\u2010cell memory formation, implying that attenuated responses induced by replication\u2010deficient vectors were likely not a consequence of impaired initial DC activation. Thus, overall, these data imply that the choice of antigen and\/or cloning strategy of exogenous antigen in combination with the route of immunization may influence the ability of attenuated CMV vectors to induce robust functional T\u2010cell memory.\n                  <\/jats:p>","DOI":"10.1111\/imm.13368","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T08:57:19Z","timestamp":1621328239000},"page":"279-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimal CD8\n                    <sup>+<\/sup>\n                    T\u2010cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses"],"prefix":"10.1111","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-4979","authenticated-orcid":false,"given":"Sandra","family":"Dimonte","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Gimeno\u2010Brias","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Marsden","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Chapman","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragati","family":"Sabberwal","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Clement","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R","family":"Humphreys","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University Cardiff 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